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Hepatoprotective Effect of Neonatal Administration of Non-Opioid Leu-Enkephalin Analogue in Adult Albino Rats Subjected to Antenatal Hypoxia

  • O. G. PinaevaEmail author
  • O. A. Lebed’ko
  • S. K. Pinaev
  • E. N. Sazonova
GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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We studied the effects of neonatal administration of non-opioid leu-enkephalin analogue peptide NALE) on the morphological parameters of the liver and redox status of 60-dayold albino rats subjected to antenatal hypoxia. In animals subjected to antenatal hypoxia, a decrease body weight and reduction of the area of hepatocytes and total area of their nucleoli were observed; these changes were accompanied by activation of free-radical processes and impairment of antioxidant defense in the liver and blood serum. Intraperitoneal administration of NALE (100 μg/kg, daily) during postnatal days 2-6 normalized body weight, hepatocyte area, and total area of their nucleoli, significantly reduced the intensity of ROS generation, and improved antioxidant protection in the liver and blood serum in 60-day-old animals subjected to antenatal hypoxia.

Key Words

antenatal hypoxia hepatocytes free radical oxidation bioactive peptides 

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • O. G. Pinaeva
    • 1
    Email author
  • O. A. Lebed’ko
    • 1
    • 2
  • S. K. Pinaev
    • 3
  • E. N. Sazonova
    • 1
    • 2
  1. 1.Far-Eastern State Medical University, Ministry of Health of the Russian FederationKhabarovskRussia
  2. 2.Khabarovsk Affiliated Branch of Far-Eastern Research Center of Respiratory Physiology and Pathology — Research Institute of Mother and Child CareKhabarovskRussia
  3. 3.Computing Center of Far-Eastern Branch of the Russian Academy of SciencesKhabarovskRussia

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