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Relaxation Properties of Contrast Media for MRI Based on Iron Oxide Nanoparticles in Different Magnetic Fields

  • V. P. Chekhonin
  • M. A. Abakumov
  • A. G. Mazhuga
  • A. N. BagdinovaEmail author
  • E. I. Demikhov
  • T. E. Demikhov
  • B. Ya. Mishkinis
  • M. V. Konstantinov
  • V. P. Tarasov
  • B. A. Shumm
  • A. A. Gippius
  • N. V. Gervits
  • A. B. Shumm
BIOTECHNOLOGIES
  • 4 Downloads

We studied dependences of T2 relaxation time on magnetic field and concentration of nanoparticles. It was found that nanocontrast media are effective under the influence of the magnetic fields in the range 0.3-7 T. Data of electron paramagnetic resonance confirm the assumption on aggregation of nanoparticles not coated with proteins in high magnetic fields.

Key Words

magnetic resonance tomography contrast agents contrasts iron oxide nanoparticles 

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References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. P. Chekhonin
    • 1
  • M. A. Abakumov
    • 1
  • A. G. Mazhuga
    • 2
  • A. N. Bagdinova
    • 3
    Email author
  • E. I. Demikhov
    • 3
  • T. E. Demikhov
    • 3
  • B. Ya. Mishkinis
    • 4
  • M. V. Konstantinov
    • 3
  • V. P. Tarasov
    • 3
  • B. A. Shumm
    • 3
  • A. A. Gippius
    • 3
  • N. V. Gervits
    • 3
  • A. B. Shumm
    • 3
  1. 1.N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian FederationMoscowRussia
  2. 2.D. I. Mendeleev University of Chemical Technology of RussiaMoscowRussia
  3. 3.P. N. Lebedev Physical Institute of the Russian Academy of SciencesMoscowRussia
  4. 4.S. P. HELPICMoscowRussia

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