Effect of Estriol, Chorionic Gonadotropin, and Oncostatin M on the Expression of Recombinase RAG-1 in Regulatory T Lymphocyte Subpopulations

  • S. V. Shirshev
  • I. V. NekrasovaEmail author
  • O. L. Gorbunova
  • E. G. Orlova

We studied the effect of estriol, chorionic gonadotropin, oncostatin M, and hormone-cytokine combinations on the expression of recombinase RAG-1 in T-regulatory (Treg) and T helper 17 (Th17) lymphocytes. It was found that estriol in a concentration corresponding to the first trimester of pregnancy increased the level of Treg (CD4+FoxP3+) cells and suppressed the formation of Th17 (CD4+RORC+) lymphocytes. This effect was nor observed after individual administration of chorionic gonadotropin and oncostatin M, but some combinations of the studied hormones with oncostatin M increased the percentage of CD4+FOXP3+ cells. In the presence of oncostatin M, the studied hormones enhanced the expression of RAG-1 in CD4+FoxP3+ cells, but not in CD4+RORC+ cells, thereby initiating of Treg T-cell receptor (TCR) revision. The mechanisms of hormone cytokine control of induction of the immune tolerance during pregnancy are discussed.

Key Words

estriol chorionic gonadotropin oncostatin M regulatory T cells recombinase-1 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • S. V. Shirshev
    • 1
  • I. V. Nekrasova
    • 1
    Email author
  • O. L. Gorbunova
    • 1
  • E. G. Orlova
    • 1
  1. 1.Institute of Ecology and Genetics of MicroorganismsPerm’ Federal Research Center of Ural Division of Russian Academy of SciencesPerm’Russia

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