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Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 3, pp 339–343 | Cite as

Semaphorin 3A Negatively Affects Proliferation of Mouse Thymus Epithelial Cells In Vitro

  • K. V. RuttoEmail author
  • K. S. Ovsyukov
  • I. V. Kudryavtsev
  • E. P. Kiseleva
PHARMACOLOGY AND TOXICOLOGY
  • 19 Downloads

We studied effects of semaphorin 3A, keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and their combinations on the proliferative activity of cortical (cTEC1-2) and medullary (mTEC3-10) thymus epithelium cell lines. Semaphorin 3A inhibited the proliferative activity of epithelial cells, while HGF and KGF, in contrast, exerted a stimulating effect. The effect of KGF and semaphorin 3A on different cell lines depended on the expression of receptors for these two factors. When the combination of two factors was used, semaphorin 3A was able to neutralize the stimulating effect of HGF and KGF. It can be assumed that semaphorin 3A synthesized in the thymus stroma, can act as a functional antagonist of HGF and KGF and have an inhibitory effect when these drugs are administered into the body for the therapeutic purpose of restoring thymus functions.

Key Words

semaphorin 3A keratinocyte growth factor (KGF) hepatocyte growth factor (HGF) thymus epithelial cells proliferation 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • K. V. Rutto
    • 1
    Email author
  • K. S. Ovsyukov
    • 1
  • I. V. Kudryavtsev
    • 1
  • E. P. Kiseleva
    • 1
    • 2
  1. 1.Institute of Experimental MedicineSt. PetersburgRussia
  2. 2.I. I. Mechnikov North-Western State Medical UniversitySt. PetersburgRussia

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