Mitochondria-Associated Matrix Metalloproteinases 2 and 9 in Acute Renal Pathologies
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Activities of MMP-2 and MMP-9 in the cytoplasm and mitochondria of kidney cells were evaluated on the models of acute renal pathologies: pyelonephritis, rhabdomyolysis, and ischemia/reperfusion of the kidney. In acute pyelonephritis, a significant increase in the level of MMP-2 and MMP-9 in kidney cells and the appearance of mitochondrial MMP-2 isoform with a lower molecular weight, but still exhibiting proteolytic activity were observed. A direct correlation between the level of MMP-2 and MMP-9 in the kidney and the severity of inflammation in pyelonephritis was revealed. Obviously, the appearance of active protease in the mitochondria of the kidney cells could have an impact on their functioning and, generally, on the fate of renal cells in this pathology.
Key Wordsmetalloproteinases pyelonephritis mitochondria oxidative stress regeneration
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- 4.Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH. Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Am. J. Physiol. Heart Circ. Physiol. 2007;292(4):H1847-H1860.CrossRefGoogle Scholar
- 5.Coker ML, Doscher MA, Thomas CV, Galis ZS, Spinale FG. Matrix metalloproteinase synthesis and expression in isolated LV myocyte preparations. Am. J. Physiol. 1999;277(2, Pt 2): H777-H787.Google Scholar
- 7.Kaneko T, Shimizu A, Mii A, Fujita E, Fujino T, Kunugi S, Du X, Akimoto T, Tsuruoka S, Ohashi R, Masuda Y, Iino Y, Katayama Y, Fukuda Y. Role of matrix metalloproteinase-2 in recovery after tubular damage in acute kidney injury in mice. Nephron Exp. Nephrol. 2012;122(1-2):23-35.CrossRefGoogle Scholar