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Low Blood Content of IL-10-Producing CD4+ T Cells as a Risk Factor for Progression of Coronary Atherosclerosis

  • A. Yu. Filatova
  • E. A. Pylaeva
  • A. V. Potekhina
  • N. Yu. Ruleva
  • E. A. Klesareva
  • N. V. Radyukhina
  • V. P. Masenko
  • A. M. Shchinova
  • E. A. Noeva
  • S. I. Provatorov
  • O. I. Afanas’eva
  • T. I. Aref’eva
Article
  • 6 Downloads

In a 2-year prospective study, prognostic significance of the blood content of IL-10-producing CD4+ T lymphocytes for progression of coronary artery atherosclerosis was assessed. Patients with verified stable angina (n=36) admitted for scheduled coronary angiography and coronary stenting were enrolled. The blood levels of CD4+FoxpP3+ Treg, CD4+IFNγ+ Th1, CD4+IL17+ Th17, CD4+IL10+ cells, sCD25, IL-10, IL-17, C-reactive protein, and lipoprotein (a) were assayed before endovascular interventions. The blood content of CD4+IL10+ T cells below 3.3% was associated with progression of coronary artery atherosclerosis (OR 12.0 (2.3, 61.0), sensitivity 77%, specificity 78%, p=0.003). No differences in other immunological parameters and common atherosclerosis risk factors in the groups were revealed. We hypothesize that the content of CD4+IL10+ T cells can be an important predictive marker for the progression of coronary atherosclerosis.

Key Words

atherosclerosis inflammation coronary arteries T lymphocytes IL-10 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. Yu. Filatova
    • 1
  • E. A. Pylaeva
    • 1
  • A. V. Potekhina
    • 1
  • N. Yu. Ruleva
    • 1
  • E. A. Klesareva
    • 1
  • N. V. Radyukhina
    • 1
  • V. P. Masenko
    • 1
  • A. M. Shchinova
    • 1
  • E. A. Noeva
    • 1
  • S. I. Provatorov
    • 1
  • O. I. Afanas’eva
    • 1
  • T. I. Aref’eva
    • 1
  1. 1.Federal Medical Research Center of Cardiology, Ministry of Health of the Russian FederationMoscowRussia

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