Low Blood Content of IL-10-Producing CD4+ T Cells as a Risk Factor for Progression of Coronary Atherosclerosis
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In a 2-year prospective study, prognostic significance of the blood content of IL-10-producing CD4+ T lymphocytes for progression of coronary artery atherosclerosis was assessed. Patients with verified stable angina (n=36) admitted for scheduled coronary angiography and coronary stenting were enrolled. The blood levels of CD4+FoxpP3+ Treg, CD4+IFNγ+ Th1, CD4+IL17+ Th17, CD4+IL10+ cells, sCD25, IL-10, IL-17, C-reactive protein, and lipoprotein (a) were assayed before endovascular interventions. The blood content of CD4+IL10+ T cells below 3.3% was associated with progression of coronary artery atherosclerosis (OR 12.0 (2.3, 61.0), sensitivity 77%, specificity 78%, p=0.003). No differences in other immunological parameters and common atherosclerosis risk factors in the groups were revealed. We hypothesize that the content of CD4+IL10+ T cells can be an important predictive marker for the progression of coronary atherosclerosis.
Key Wordsatherosclerosis inflammation coronary arteries T lymphocytes IL-10
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- 2.Filatova AYu, Pylaeva EA, Potekhina AV, Osokina AK, Pogorelova OA, Tripoten MI, Balakhonova TV, Provatorov SI, Noeva EA, Klesareva EA, Afanasieva OI, Arefieva TI. Subpopulation Composition of CD4+ T lymphocytes as Factor Contributing to the Progression of Atherosclerosis of Carotid Arteries. Kardiologiya. 2017;57(4):64-71. Russian.Google Scholar
- 4.Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kühn R, Müller W, Trinchssieri G, Sher A. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J. Immunol. 1996;157(2):798-805.Google Scholar
- 6.Gurbel PA, Kreutz RP, Bliden KP, DiChiara J, Tantry US. Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with longterm quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression. Am. Heart. J. 2008;155(1):56-61.CrossRefGoogle Scholar
- 13.Szodoray P, Timar O, Veres K, Der H, Szomjak E, Lakos G, Aleksza M, Nakken B, Szegedi G, Soltesz P. TH1/TH2 imbalance, measuredbycirculating and intracytoplasmic inflammatory cytokines — immunological alterations in acute coronary syndrome and stable coronary artery disease. Scand. J. Immunol. 2006;64(3):336-344.CrossRefGoogle Scholar
- 14.Trinchieri G. Interleukin-10 production by effector T cells: Th1 cells show self control. J. Exp. Med;204(2):239-243.Google Scholar
- 15.Wigren M, Björkbacka H, Andersson L, Ljungcrantz I, Fredrikson GN, Persson M, Bryngelsson C, Hedblad B, Nilsson J. Low levels of circulating CD4+Foxp3+ T cells are associated with an increased risk for development of myocardial infarction but not for stroke. Arterioscler. Thromb. Vasc. Biol. 2012;32(8):2000-2004.CrossRefGoogle Scholar