Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 3, pp 326–329 | Cite as

Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice

  • T. V. DavydovaEmail author
  • M. A. Gruden
  • V. S. Kudrin
  • V. B. Narkevich
  • L. A. Vetrile
  • I. A. Zakharova
  • R. D. E. Sewell

Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.

Key Words

memory antibodies to glutamate neurotransmitters aging 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • T. V. Davydova
    • 1
    Email author
  • M. A. Gruden
    • 2
  • V. S. Kudrin
    • 3
  • V. B. Narkevich
    • 3
  • L. A. Vetrile
    • 1
  • I. A. Zakharova
    • 1
  • R. D. E. Sewell
    • 4
  1. 1.Research Institute of General Pathology and PathophysiologyMoscowRussia
  2. 2.P. K. Anokhin Research Institute of Normal PhysiologyMoscowRussia
  3. 3.V. V. Zakusov Research Institute of PharmacologyMoscowRussia
  4. 4.School of Pharmacy and Pharmaceutical SciencesCardiff UniversitCardiffUK

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