Correlation-and-Spectral Analysis of Time Series for Microcirculatory Parameters in Vessels of Symmetrical Organs
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The correlation relationships between microcirculatory parameters were studied in vessels of symmetrical organs in humans. Parameters of microcirculation in healthy volunteers were measured by the method of laser Doppler flowmetry (LDF). LDF-signal transducers were placed symmetrically on the lower parts of the right and left shoulders (3 cm above the elbow bend). Correlations between various components of the amplitude-frequency spectrum for blood flow fluctuations (myogenic, neurogenic, respiratory, and cardiac) were evaluated on symmetrical sides. A significant correlation was found for the mean value of vascular perfusion on the right side with the neurogenic, myogenic, respiratory, and cardiac components on the same side. However, the mean value of vascular perfusion on the light side was interrelated only with the cardiac component. A positive correlation was revealed between the neurogenic and myogenic components on the left side. However, the neurogenic component on the right side was positively related to the myogenic component on the opposite side. Asymmetry of correlation relationships was also observed for the respiratory and cardiac components of study spectrum. Our results illustrate the specific regulation of microcirculatory blood flow in paired organs, which is associated with the existence of functional asymmetry. The physiological mechanisms for this asymmetry require further experimental and clinical studies.
Key Wordsmicrocirculation asymmetry laser Doppler flowmetry
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- 1.Kozlov VI, Azizov GA, Gurova OA, Litvin FB. Laser Doppler Flowmetry in the Assessment of the State and Disorders of Blood Microcirculation. Moscow, 2012. Russian.Google Scholar
- 2.Krupatkin AI, Sidorov VV. Laser Doppler Flowmetry of Blood Microcirculation. A Guide for Doctors. Moscow, 2005. Russian.Google Scholar
- 3.Krupatkin AI, Sidorov VV, Kutepov IA. Analysis of information processes in microvascular networks using wavelet analysis of oscillatory structures of blood flow. Regionar. Krovoobr. Mikrotsirk. 2009;8(3):21-31. Russian.Google Scholar
- 5.Mikhailichenko LA. Endothelial component in the mechanisms of vascular tone regulation in paired formations. Laser Doppler flowmetry data. Regionar. Krovoobr. Mikrotsirk. 2008;7(4):71-80. Russian.Google Scholar
- 11.Goltsov A, Anisimova AV, Zakharkina M, Krupatkin AI, Sidorov VV, Sokolovski SG, Rafailov E. Bifurcation in blood oscillatory rhythms for patients with ischemic stroke: a small scale clinical trial using laser Doppler flowmetry and computational modeling of vasomotion. Front. Physiol. 2017;8:160. doi: https://doi.org/10.3389/fphys.2017.00160.CrossRefGoogle Scholar