Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 4, pp 442–445 | Cite as

α-Tocopherol Reduces Morphological Changes and Oxidative Stress during Gentamicin-Induced Acute Renal Failure

  • N. Stojiljkovic
  • S. Ilic
  • M. Veljkovic
  • J. Todorovic
  • M. Mladenovic
Article
  • 11 Downloads

We studied the effect of α-tocopherol on gentamicin-induced morphological and functional changes in the kidneys of Wistar rats. Special attention was paid to the ability of α-tocopherol administered in combination with gentamicin to correct ultrastructural changes in the glomerular basal membrane and tubules. Combined treatment with α-tocopherol (100 mg/kg) and gentamicin (100 mg/kg) led to correction of histopathological and biochemical changes and oxidative injury to the kidneys induced by this antibiotic.

Key Words

α-tocopherol gentamicin glomerular basal membrane Wistar rats 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. Stojiljkovic
    • 1
  • S. Ilic
    • 1
  • M. Veljkovic
    • 1
  • J. Todorovic
    • 2
  • M. Mladenovic
    • 2
  1. 1.Institute of PhysiologyNisSerbia
  2. 2.Faculty of MedicineUniversity of NisNisSerbia

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