Aquaculture International

, Volume 27, Issue 6, pp 1825–1834 | Cite as

Dietary β-1,3/1,6-glucans improve the effect of a multivalent vaccine in Atlantic salmon infected with Moritella viscosa or infectious salmon anemia virus

  • Fernando de O. Roberti Filho
  • João Fernando Albers Koch
  • Christian Wallace
  • Miguel Costa LealEmail author


The immunomodulatory properties of β-glucans are well documented for several animal species. However, little is known on their use as enhancers of non-specific and specific responses against Moritella viscosa and infectious salmon anemia (ISA) virus, which are two major pathogens affecting the Atlantic salmon aquaculture industry. The present study assessed the effects of dietary β-1,3/1,6-glucans (MacroGard®) and vaccination on the survival of Atlantic salmon (Salmo salar) post-smolts challenged with M. viscosa or ISA virus. Dietary supplementation decreased mortality in both unvaccinated (55.4%; RPSend 19.9) and vaccinated (9.3%; RPSend 86.6) M. viscosa-challenged fish compared to the non-supplemented groups (69.1% and 28.3% mortality in unvaccinated and vaccinated fish, respectively; RPSend 59 for vaccinate non-supplemented fish). Similarly, mortality of ISA virus-challenged fish decreased from 87.5% in vaccinated fish without supplementation (RPSend 9.2) to 70.9% in the supplemented and vaccinated group (RPSend 26.4). In summary, these findings show that dietary β-glucans increase Atlantic salmon resistance and improve the protective effect of vaccines against the tested pathogens.


Atlantic salmon Vaccination Glucans Winter ulcer disease ISA virus 



The authors would like to thank Biorigin for intellectual support, and for providing the β-glucan supplements.

Funding information

Biorigin provided financial support. MC Leal was funded by the Portuguese Science Foundation (SFRH/BPD/115298/2016).

Compliance with ethical standards

Conflict of interest

Fernando Roberti Filho and João Albers Koch are both employed by Biorigin Company, and Christian Wallace is employed by VESO Vikan. Miguel Costa Leal has received a research grant from Fundação para a Ciência e Tecnologia (Portugal).

Ethical approval

All applicable international, national, and institutional guidelines for the care and use of animals were followed by the authors.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Biorigin CompanySao PauloBrazil
  2. 2.VESO Vikan, Aquamedical Contract ResearchNamsosNorway
  3. 3.MARE–Marine and Environmental Sciences Centre, Faculty of SciencesUniversity of LisbonLisbonPortugal

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