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Annals of Biomedical Engineering

, Volume 47, Issue 1, pp 126–137 | Cite as

Design Method Using Statistical Models for Miniature Left Ventricular Assist Device Hydraulics

  • P. Alex SmithEmail author
  • Yaxin Wang
  • Shelby A. Bieritz
  • Luiz C. Sampaio
  • William E. Cohn
  • Ralph W. Metcalfe
  • O. H. Frazier
Article

Abstract

Left ventricular assist devices (LVADs) are increasingly used to treat heart failure patients. These devices’ impeller blades and diffuser vanes must be designed for hydraulic performance and hemocompatibility. The traditional design method, applying mean-line theory, is not applicable to the design of small-scale pumps such as miniature LVADs. Furthermore, iterative experimental testing to determine how each geometric variable affects hydraulic performance is time and labor intensive. In this study, we tested a design method wherein empirical hydraulic results are used to establish a statistical model to predict pump hydraulic performance. This method was used to design an intra-atrial blood pump. Five geometric variables were chosen, and each was assigned two values to define the variable space. The experimental results were then analyzed with both correlation analysis and linear regression modeling. To validate the linear regression models, 2 test pumps were designed: mean value of each geometric variable within the boundaries, and random value of each geometric variable within the boundaries. The statistical model accurately predicted the hydraulic performance of both pump designs within the boundary space. This method could be expanded to include more geometric variables and broader boundary conditions, thus accelerating the design process for miniature LVADs.

Keywords

Left ventricular assist device Blood pump Hydraulic performance Statistical modeling Hydraulic torque Mechanical circulatory support Linear regression model Correlation analysis 

Abbreviations

IAP

Intra-atrial pump

MLT

Mean-line theory

BEP

Best efficiency point

Glossary of Terms

G

Pressure-flow gradient (mmHg/L/min)

Ph

Hydraulic power (W)

Q

Volumetric flow (L/min)

Δp

Pressure rise across the pump (mmHg)

Pm

Mechanical power (W)

I

Electrical current (A)

N

Rotational speed (rpm)

Τ

Torque (mNm)

ηh

Hydraulic efficiency (%)

Notes

Acknowledgments

Stephen N. Palmer, PhD, ELS, contributed to the editing of the manuscript. Juan Fernandez machined custom testing equipment. Scott A. Weldon, MA, CMI, FAMI, illustrated Fig. 1a. The Stanford and Joan Alexander Research Foundation supported this work.

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Copyright information

© Biomedical Engineering Society 2018

Authors and Affiliations

  1. 1.Cardiovascular Surgical Research LaboratoryTexas Heart InstituteHoustonUSA
  2. 2.Department of Mechanical EngineeringUniversity of HoustonHoustonUSA
  3. 3.Department of BioengineeringRice UniversityHoustonUSA
  4. 4.Center for Device Innovation, Johnson & JohnsonHoustonUSA

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