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Hierarchical model for strain generalized streaming potential induced by the canalicular fluid flow of an osteon

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Abstract

A hierarchical model is developed to predict the streaming potential (SP) in the canaliculi of a loaded osteon. Canaliculi are assumed to run straight across the osteon annular cylinder wall, while disregarding the effect of lacuna. SP is generalized by the canalicular fluid flow. Analytical solutions are obtained for the canalicular fluid velocity, pressure, and SP. Results demonstrate that SP amplitude (SPA) is proportional to the pressure difference, strain amplitude, frequency, and strain rate amplitude. However, the key loading factor governing SP is the strain rate, which is a representative loading parameter under the specific physiological state. Moreover, SPA is independent of canalicular length. This model links external loads to the canalicular fluid pressure, velocity, and SP, which can facilitate further understanding of the mechanotransduction and electromechanotransduction mechanisms of bones.

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Authors and Affiliations

  1. College of Mechanics, Shanxi Key Lab. of Material Strength & Structural Impact, Taiyuan University of Technology, 030024, Taiyuan, China

    Xiao-Gang Wu, Wei-Lun Yu, Hai-Peng Cen & Yan-Qin Wang

  2. Institute of Applied Mechanics and Biomedical Engineering, Taiyuan University of Technology, 030024, Taiyuan, China

    Yuan Guo & Wei-Yi Chen

Authors
  1. Xiao-Gang Wu
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  2. Wei-Lun Yu
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  3. Hai-Peng Cen
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  4. Yan-Qin Wang
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  5. Yuan Guo
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  6. Wei-Yi Chen
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Correspondence to Wei-Yi Chen.

Additional information

The project was supported by the OIT of Higher Learning Institutions of Shanxi, the National Natural Science Foundation of China (11302143, 11472185), and Natural Science Fund of Shanxi (2014021013).

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Wu, XG., Yu, WL., Cen, HP. et al. Hierarchical model for strain generalized streaming potential induced by the canalicular fluid flow of an osteon. Acta Mech Sin 31, 112–121 (2015). https://doi.org/10.1007/s10409-015-0002-z

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  • DOI: https://doi.org/10.1007/s10409-015-0002-z

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