Advertisement

Stream of droplets as an actuator for oscillatory flows in microfluidics

  • Pedro Andrés Basilio
  • Aimee M. Torres Rojas
  • Eugenia Corvera PoiréEmail author
  • Luis F. OlguínEmail author
Research Paper
  • 120 Downloads

Abstract

Oscillatory or pulsatile flow in microfluidic devices is usually imposed and controlled by external electronic or mechanical actuators, limiting the chips’ portability and increasing the complexity of their control. Here, we have developed a microfluidic platform that generates an oscillatory motion in a fluid with zero-mean flow, using a continuous stream of droplets as the pulsatile power source. The passage of each droplet produces an oscillatory flow in an orthogonal channel that we use to periodically force an interface between two non-miscible fluids. A detailed analysis of the dynamics of the pulsatile fluid interface revealed that its dynamics is dominated by a single oscillatory mode with precisely the same frequency of the passing droplets. As the droplets were formed by syringe-pump-driven flows of water and oil and because their frequency production can be easily controlled, it was possible to impose specific oscillatory frequencies to the fluid interface. By studying the interface movement, we propose a simple way to estimate the pressure drop caused by the flow of each droplet. This work represents a new way to produce pulsatile flow employing only continuous flows and it is an example of a microfluidic functional device that requires minimal external equipment for functioning.

Keywords

Pulsatile flow Droplet pressure drop Microfluidic actuation Microfluidic droplets Oscillatory motion Interface dynamics 

Notes

Acknowledgements

A.T. acknowledges financial support from Consejo Nacional de Ciencia y Tecnología (CONACyT-México) through fellowship no. 245675. All authors acknowledge financial support from CONACyT through Projects nos. 219584 and 153208. E.C.P. and L.F.O. acknowledge financial support from Facultad de Química UNAM through PAIP nos. 5000-9011 and 5000-9023.

Author contributions

ECP conceptualized the project. PAB performed the investigation. AT carried out the data curation and formal analysis. ECP and LFO did the funding acquisition and supervised the investigation. AT, ECP and LFO wrote the original draft, performed review and edited the final manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Supplementary material

10404_2019_2237_MOESM1_ESM.pdf (1.6 mb)
Supplementary material 1 (PDF 1651 kb)

References

  1. Abolhasani M, Jensen KF (2016) Oscillatory multiphase flow strategy for chemistry and biology. Lab Chip 16:2775–2784.  https://doi.org/10.1039/c6lc00728g CrossRefGoogle Scholar
  2. Alizadehgiashi M, Khabibullin A, Li Y et al (2018) Shear-induced alignment of anisotropic nanoparticles in a single-droplet oscillatory microfluidic platform. Langmuir 34:322–330.  https://doi.org/10.1021/acs.langmuir.7b03648 CrossRefGoogle Scholar
  3. Baroud CN, Gallaire F, Dangla R (2010) Dynamics of microfluidic droplets. Lab Chip 10:2032.  https://doi.org/10.1039/c001191f CrossRefGoogle Scholar
  4. Bengtsson K, Christoffersson J, Mandenius C-F, Robinson ND (2018) A clip-on electroosmotic pump for oscillating flow in microfluidic cell culture devices. Microfluid Nanofluidics 22:27.  https://doi.org/10.1007/s10404-018-2046-4 CrossRefGoogle Scholar
  5. Bordbar A, Taassob A, Zarnaghsh A, Kamali R (2018) Slug flow in microchannels: numerical simulation and applications. J Ind Eng Chem 62:26–39.  https://doi.org/10.1016/j.jiec.2018.01.021 CrossRefGoogle Scholar
  6. Brown D (2016) Tracker Video Analysis and Modeling Tool (Version 4.94). http://physlets.org/tracker/
  7. Bruus H (2008) Theoretical Microfluidics. Oxford University Press Inc., New YorkGoogle Scholar
  8. Chen H, Meng Q, Li J (2015) Thin lubrication film around moving bubbles measured in square microchannels. Appl Phys Lett 107:141608.  https://doi.org/10.1063/1.4933105 CrossRefGoogle Scholar
  9. Cheung P, Toda-Peters K, Shen AQ (2012) In situ pressure measurement within deformable rectangular polydimethylsiloxane microfluidic devices. Biomicrofluidics 6:026501.  https://doi.org/10.1063/1.4720394 CrossRefGoogle Scholar
  10. Duncan PN, Nguyen TV, Hui EE (2013) Pneumatic oscillator circuits for timing and control of integrated microfluidics. Proc Natl Acad Sci 110:18104–18109.  https://doi.org/10.1073/pnas.1310254110 CrossRefGoogle Scholar
  11. Garstecki P, Fuerstman MJ, Stone HA, Whitesides GM (2006) Formation of droplets and bubbles in a microfluidic T-junction—scaling and mechanism of break-up. Lab Chip 6:437–446.  https://doi.org/10.1039/b510841a CrossRefGoogle Scholar
  12. Jakiela S (2016) Measurement of the hydrodynamic resistance of microdroplets. Lab Chip 16:3695–3699.  https://doi.org/10.1039/c6lc00854b CrossRefGoogle Scholar
  13. Jo K, Chen Y-L, de Pablo JJ, Schwartz DC (2009) Elongation and migration of single DNA molecules in microchannels using oscillatory shear flows. Lab Chip 9:2348–2355.  https://doi.org/10.1039/b000000x/Jo CrossRefGoogle Scholar
  14. Jose BM, Cubaud T (2014) Formation and dynamics of partially wetting droplets in square microchannels. RSC Adv 4:14962–14970.  https://doi.org/10.1039/C4RA00654B CrossRefGoogle Scholar
  15. Kalantarifard A, Alizadeh Haghighi E, Elbuken C (2018) Damping hydrodynamic fluctuations in microfluidic systems. Chem Eng Sci 178:238–247.  https://doi.org/10.1016/j.ces.2017.12.045 CrossRefGoogle Scholar
  16. Kang C, Roh C, Overfelt RA (2014) RSC advances pressure-driven deformation with soft polydimethylsiloxane (PDMS) by a regular syringe pump: challenge to the classical fluid dynamics by comparison of experimental and theoretical results. RSC Adv 4:3102–3112.  https://doi.org/10.1039/c3ra46708b CrossRefGoogle Scholar
  17. Khoshmanesh K, Almansouri A, Albloushi H et al (2015) A multi-functional bubble-based microfluidic system. Sci Rep 5:9942.  https://doi.org/10.1038/srep09942 CrossRefGoogle Scholar
  18. Kim S-J, Yokokawa R, Cai Lesher-Perez S, Takayama S (2015) Multiple independent autonomous hydraulic oscillators driven by a common gravity head. Nat Commun 6:7301.  https://doi.org/10.1038/ncomms8301 CrossRefGoogle Scholar
  19. Kim G, Van Dang B, Kim S-J (2018) Stepwise waveform generator for autonomous microfluidic control. Sensors Actuators B Chem 266:614–619.  https://doi.org/10.1016/j.snb.2018.03.160 CrossRefGoogle Scholar
  20. Ładosz A, von Rohr PR (2018) Pressure drop of two-phase liquid-liquid slug flow in square microchannels. Chem Eng Sci 191:398–409.  https://doi.org/10.1016/j.ces.2018.06.057 CrossRefGoogle Scholar
  21. Leslie DC, Easley CJ, Seker E et al (2009) Frequency-specific flow control in microfluidic circuits with passive elastomeric features. Nat Phys 5:231–235.  https://doi.org/10.1038/nphys1196 CrossRefGoogle Scholar
  22. Lestari G, Salari A, Abolhasani M, Kumacheva E (2016) A microfluidic study of liquid-liquid extraction mediated by carbon dioxide. Lab Chip 16:2710–2718.  https://doi.org/10.1039/c6lc00597g CrossRefGoogle Scholar
  23. Lignel S, Salsac A-V, Drelich A et al (2017) Water-in-oil droplet formation in a flow-focusing microsystem using pressure- and flow rate-driven pumps. Colloids Surfaces A Physicochem Eng Asp 531:164–172.  https://doi.org/10.1016/j.colsurfa.2017.07.065 CrossRefGoogle Scholar
  24. McDonald JC, Duffy DC, Anderson JR et al (2000) Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21:27–40CrossRefGoogle Scholar
  25. Mosadegh B, Kuo C-H, Tung Y-C et al (2010) Integrated elastomeric components for autonomous regulation of sequential and oscillatory flow switching in microfluidic devices. Nat Phys 6:433–437.  https://doi.org/10.1038/nphys1637 CrossRefGoogle Scholar
  26. Qu J, Wu H, Cheng P et al (2017) Recent advances in MEMS-based micro heat pipes. Int J Heat Mass Transf 110:294–313.  https://doi.org/10.1016/j.ijheatmasstransfer.2017.03.034 CrossRefGoogle Scholar
  27. Raj A, Sen AK (2016) Flow-induced deformation of compliant microchannels and its effect on pressure–flow characteristics. Microfluid Nanofluidics 20:31.  https://doi.org/10.1007/s10404-016-1702-9 CrossRefGoogle Scholar
  28. Sajeesh P, Doble M, Sen AK (2014) Hydrodynamic resistance and mobility of deformable objects in microfluidic channels. Biomicrofluidics 8:054112.  https://doi.org/10.1063/1.4897332 CrossRefGoogle Scholar
  29. Tabeling P, Chabert M, Dodge A et al (2004) Chaotic mixing in cross-channel micromixers. Philos Trans R Soc A Math Phys Eng Sci 362:987–1000.  https://doi.org/10.1098/rsta.2003.1358 CrossRefGoogle Scholar
  30. Vanapalli SA, Banpurkar AG, Van Den Ende D et al (2009) Hydrodynamic resistance of single confined moving drops in rectangular microchannels. Lab Chip 9:982–990.  https://doi.org/10.1039/b815002h CrossRefGoogle Scholar
  31. Vázquez-Vergara P, Torres Rojas AM, Guevara-Pantoja PE et al (2017) Microfluidic flow spectrometer. J Micromech Microeng 27:077001.  https://doi.org/10.1088/1361-6439/aa71c2 CrossRefGoogle Scholar
  32. Wang B, Xu JL, Zhang W, Li YX (2011) A new bubble-driven pulse pressure actuator for micromixing enhancement. Sensors Actuators A Phys 169:194–205.  https://doi.org/10.1016/j.sna.2011.05.017 CrossRefGoogle Scholar
  33. Wang X, Zhao D, Phan DTT et al (2018) A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function. Lab Chip 18:2167–2177.  https://doi.org/10.1039/c8lc00236c CrossRefGoogle Scholar
  34. Xie Y, Chindam C, Nama N et al (2015) Exploring bubble oscillation and mass transfer enhancement in acoustic-assisted liquid-liquid extraction with a microfluidic device. Sci Rep 5:12572.  https://doi.org/10.1038/srep12572 CrossRefGoogle Scholar
  35. Zhang Q, Zhang M, Djeghlaf L et al (2017) Logic digital fluidic in miniaturized functional devices: perspective to the next generation of microfluidic lab-on-chips. Electrophoresis 38:953–976.  https://doi.org/10.1002/elps.201600429 CrossRefGoogle Scholar
  36. Zhou H, Yao Y, Chen Q et al (2013) A facile microfluidic strategy for measuring interfacial tension. Appl Phys Lett 103:234102.  https://doi.org/10.1063/1.4838616 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratorio de Biofisicoquímica, Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMexico
  2. 2.Departamento de Física y Química Teórica, Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMexico
  3. 3.Imaging Sciences and Biomedical Engineering Division, St Thomas HospitalKings CollegeLondonUK

Personalised recommendations