Manipulation of bio-micro/nanoparticles in non-Newtonian microflows

  • Tian Fei
  • Feng Qiang
  • Qinghua Chen
  • Chao LiuEmail author
  • Li TiejunEmail author
  • Jiashu SunEmail author
Research Paper
Part of the following topical collections:
  1. Particle motion in non-Newtonian microfluidics


Most bio-micro/nanoparticles, including cells, platelets, bacteria, and extracellular vesicles, are inherently suspended in biofluids (i.e., blood) with non-Newtonian fluid characteristics. Understanding migration behaviors of bioparticles in non-Newtonian microfluidics is of significance in label-free manipulation of bioparticles, playing important roles in cell analysis and disease diagnostics. This review presents recent advances in focusing and sorting of bio-micro/nanoparticles by non-Newtonian microfluidics. Principle and examples for passive and active manipulation of bioparticles in non-Newtonian and non-Newtonian/Newtonian hybrid microflows are highlighted. Limitations and perspectives of non-Newtonian microfluidics for clinical applications are discussed.



This work was supported financially by NSFC (21622503), Youth Innovation Promotion Association CAS (2016035), and the open research fund of Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University (KF201804).


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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Mechanical EngineeringHebei University of TechnologyTianjinChina
  2. 2.CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina
  3. 3.School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast UniversityNanjingChina
  4. 4.University of Chinese Academy of SciencesBeijingChina

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