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Particle squeezing in narrow confinements

  • Zhifeng Zhang
  • Jie Xu
  • Corina Drapaca
Review
  • 315 Downloads

Abstract

Many lab-on-a-chip applications require processing of droplets, cells, and particles using narrow confinements. The physics governing the process of a particle squeezing through narrow confinement is complex. Various models and applications have been developed in this area in recent years. In the present paper, we review the physics, modeling approaches, and designs of narrow confinements for the control of deformable droplets, cells, and particles. This review highlights the interdisciplinary nature of the problem, since the experimental, analytical, and numerical methods used in studies of particle squeezing through narrow confinements come from various fields of science and technology.

Keywords

Droplets Cells Particles Narrow confinements Soft matter Chip design Fluid mechanics Chemical engineering 

Notes

Acknowledgements

Zhifeng Zhang thanks the support of Harvey & Geraldine Brush Fellowship and Max & Joan Schlienger Scholarship awarded by College of Engineering, the Pennsylvania State University.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Engineering Science and MechanicsThe Pennsylvania State UniversityState CollegeUSA
  2. 2.Department of Mechanical and Industrial EngineeringUniversity of Illinois at ChicagoChicagoUSA

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