Particle squeezing in narrow confinements

  • Zhifeng ZhangEmail author
  • Jie Xu
  • Corina DrapacaEmail author


Many lab-on-a-chip applications require processing of droplets, cells, and particles using narrow confinements. The physics governing the process of a particle squeezing through narrow confinement is complex. Various models and applications have been developed in this area in recent years. In the present paper, we review the physics, modeling approaches, and designs of narrow confinements for the control of deformable droplets, cells, and particles. This review highlights the interdisciplinary nature of the problem, since the experimental, analytical, and numerical methods used in studies of particle squeezing through narrow confinements come from various fields of science and technology.


Droplets Cells Particles Narrow confinements Soft matter Chip design Fluid mechanics Chemical engineering 



Zhifeng Zhang thanks the support of Harvey & Geraldine Brush Fellowship and Max & Joan Schlienger Scholarship awarded by College of Engineering, the Pennsylvania State University.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Engineering Science and MechanicsThe Pennsylvania State UniversityState CollegeUSA
  2. 2.Department of Mechanical and Industrial EngineeringUniversity of Illinois at ChicagoChicagoUSA

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