A temperature-based diagnostic approach for paper-based microfluidics
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We present the potential of a quantitative temperature-based diagnostic approach for paper-based microfluidics, extending the work of Terzis et al. (J Colloid Interface Sci 504:751–757, 2017) which demonstrated a significant heat release at the liquid front during capillary-driven flows in cellulosic materials. Here, we investigate the applicability of biological fluids to provide a temperature rise at the imbibition front, and successfully demonstrate a monotonic trend between the level of local temperature rise and the concentration of specific analytes. In addition, effects of paper thickness and width are also examined.
KeywordsPaper-based microfluidics Quantitative diagnostics Capillary thermodynamics
A. Terzis acknowledges the support of Alexander von Humboldt (AvH) foundation. I. Zarikos acknowledges the support received under the ERC Grant Agreement No. 341225. Special thanks go to Dr. Eleftheria Roumeli (California Institute of Technology) for characterizing the paper samples. The authors are also grateful to Prof. S. Majid Hassanizadeh (Utrecht University) for his overall contribution.
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