The relationship of spleen stiffness value measured by shear wave elastography with age, gender, and spleen size in healthy volunteers
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The aim of this study is to evaluate spleen stiffness values with shear wave elastography (SWE) quantitatively in healthy adults and investigate the relationship of spleen stiffness with age, gender, and spleen size.
This study included 65 healthy individuals. Spleen stiffness measurement was obtained with 2 dimensional (2-D) SWE method from the middle portion of spleen and calculated in kilopascals by taking the average of three valid measurements. Longitudinal and transverse spleen sizes were measured. The relationship of spleen stiffness with age, gender, and spleen size was investigated. The association between spleen size and age and gender was also evaluated.
The mean spleen stiffness value was 13.82 ± 2.91 kPa, and the spleen stiffness was not affected by age, gender, or spleen size. Longitudinal spleen size was significantly lower in females than that in males. Moreover, there was a significant negative correlation between longitudinal spleen size and age (r = 0.247, p = 0.048).
Spleen stiffness can be quantitatively measured by 2-D SWE, and the spleen stiffness is not affected by age, gender, and spleen size. The values obtained in this study can be used as normal base values in examination of different spleen pathologies.
KeywordsSpleen Shear wave elastography Ultrasonography
Compliance with ethical standards
Conflict of interest
Eda Albayrak, Sadık Server declare that they have no conflict of interest.
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients for being included in the study.
- 1.Sakata N, Yoshimatsu G, Kodama S. The spleen as an optimal site for islet transplantation and a source of mesenchymal stem cells. Int J Mol Sci. 2018;7:19 (pii: E1391).Google Scholar
- 2.Li L, Duan M, Chen W, et al. The spleen in liver cirrhosis: revisiting an old enemy with novel targets. J Transl Med. 2017;23:11.Google Scholar
- 26.Okoye IJ, Agwu KK. Ochie K Sonographic splenic sizes in normal adult Nigerian population. West Afr J Radio. 2005;12:37–43.Google Scholar
- 27.Chakraborti S, Saha N, Debbarma B, et al. Normal spleen length by ultrasonography in adults of Tripura. J Dent Med Sci. 2016;15:55–60.Google Scholar