Journal of Medical Ultrasonics

, Volume 46, Issue 1, pp 3–14 | Cite as

Ultrasound scattering by aggregated red blood cells in patients with diabetes

  • Hiroki SakakiEmail author
  • Mototaka Arakawa
  • Satoshi Yashiro
  • Yusuke Todate
  • Yasushi Ishigaki
  • Hiroshi Kanai
Original Article



To develop methods for noninvasively and quantitatively measuring blood glucose levels.


In the present study, we evaluated the degree of red blood cell (RBC) aggregation at a low shear rate robustly by introducing two new parameters determined from changes in the scattering power spectrum of the echoes from the intravascular lumen before and after cessation of blood flow. We also considered the clinical significance of these parameters and the change in sizes estimated by the conventional method by comparing them with the blood glucose level obtained just before the ultrasonic measurements. We performed the measurements in one healthy subject and 11 diabetic patients.


A correlation was found between one of the proposed parameters and the blood glucose level. However, the p value was not very high, and one of the reasons for the decline of the correlation will be that some factors other than blood glucose also affect RBC aggregation.


The proposed method has potential for clinical application after elucidation of the various factors affecting RBC aggregation.


Ultrasound scattering Red blood cells Aggregation Blood glucose levels 



This work was partly supported by MEXT/JSPS KAKENHI through Grant No. 16K14272.

Compliance with ethical standards

This study was approved by the Institutional Review Board of Iwate Medical University (Approval Number: H26-79). Written informed consent was obtained from study participants.

Conflict of interest

The authors have no conflicts of interest with regard to the presented research.


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Copyright information

© The Japan Society of Ultrasonics in Medicine 2018

Authors and Affiliations

  • Hiroki Sakaki
    • 1
    Email author
  • Mototaka Arakawa
    • 1
    • 2
  • Satoshi Yashiro
    • 3
  • Yusuke Todate
    • 3
  • Yasushi Ishigaki
    • 3
  • Hiroshi Kanai
    • 1
    • 2
  1. 1.Graduate School of Biomedical EngineeringTohoku UniversitySendaiJapan
  2. 2.Graduate School of EngineeringTohoku UniversitySendaiJapan
  3. 3.Department of Internal Medicine Division of Diabetes and MetabolismIwate Medical UniversityMoriokaJapan

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