Journal of Medical Ultrasonics

, Volume 46, Issue 1, pp 99–104 | Cite as

Transabdominal ultrasound elastography of the esophagogastric junction predicts reflux esophagitis

  • Hiroki Suhara
  • Yoshiki HirookaEmail author
  • Hiroki Kawashima
  • Eizaburo Ohno
  • Takuya Ishikawa
  • Masanao Nakamura
  • Ryoji Miyahara
  • Masatoshi Ishigami
  • Senju Hashimoto
  • Hidemi Goto
Original Article



Abdominal ultrasound (US) can visualize the esophagogastric junction (EGJ) as a hyperechoic area in the dorsal portion of the lateral segment of the liver. We prospectively evaluated the EGJ using US elastography (US-EG) in patients with reflux esophagitis (RE) to examine prediction of distal esophageal function.


Of 108 patients undergoing US-EG and esophagogastroduodenoscopy, 102 in whom the EGJ was observed for ≥ 15 s were included. The subjects were divided into a RE group (n = 41, Grade M/A/B:24/13/4 according to modified Los Angeles Classification) and a non-RE group (n = 61). Direct strain elastography (LOGIQ E9, GE Healthcare), which gives a semi-quantitative elasticity index within a region of interest including the lateral segment, was used as a standard for measurement of the change in stiffness (CS) at the EGJ.


The number of CS as determined by US-EG was 6.0 (5.5–6.7) in the RE group and 8.6 (6.6–10.0) in the non-RE group (P < 0.0001). In ROC analysis, the AUC was 0.8415 for diagnosis of RE using the number of CS. At a cut-off of 7.7, the sensitivity, specificity, and accuracy for diagnosis were 92.7, 65.6, and 74.5%, respectively.


The presence of RE can be predicted based on US-EG.


Reflux esophagitis Transabdominal-ultrasound Elastography 


Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Ethical statements

Informed consent to the protocol was obtained from all patients. The study was approved by our institutional ethics committee for human research.


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Copyright information

© The Japan Society of Ultrasonics in Medicine 2018

Authors and Affiliations

  • Hiroki Suhara
    • 1
  • Yoshiki Hirooka
    • 2
    Email author
  • Hiroki Kawashima
    • 1
  • Eizaburo Ohno
    • 1
  • Takuya Ishikawa
    • 1
  • Masanao Nakamura
    • 1
  • Ryoji Miyahara
    • 1
  • Masatoshi Ishigami
    • 1
  • Senju Hashimoto
    • 3
  • Hidemi Goto
    • 1
  1. 1.Department of Gastroenterology and HepatologyNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Department of EndoscopyNagoya University HospitalNagoyaJapan
  3. 3.Department of Liver, Biliary Tract and Pancreas DiseasesFujita Health UniversityToyoakeJapan

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