Analysis of survival rates and prognostic factors among patients with oral squamous cell carcinoma
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Aim: The aim of the study was to estimate global and accumulated survival rates as well as prognostic factors among patients with oral squamous cell carcinoma (OSCC). Subject and methods: Data from the previous 5 years were extracted from patient charts at a cancer reference center. The occurrence of death resulting from the malignant tumor in patients with a diagnosis of OSCC was the dependent variable. The independent variables were tumor site, degree of cell differentiation, clinical staging, data of histopathological determination of OSCC, socio-demographic characteristics, smoking habit and treatment modality. Kaplan-Meier survival curves were created. Differences were analyzed using the log-rank and Wilcoxon tests. The Cox regression model was employed to evaluate factors associated with survival, with the calculation of hazard ratios (HR) (α = 5%). Results: The global survival rate was 57%. The stage of the tumor exercised a direct influence on accumulated survival. In the first year of evaluation, the survival rate of patients in stages I and II was 92.6%. The Cox regression analysis revealed the following variables to be significantly associated with survival: T classification of the clinical staging (HR = 2.283; 95% CI: 1.115–4.673) and degree of tumor invasion (HR = 1.834; 95% CI: 1.041–3.232). Conclusion: Clinical stage and degree of tumor invasion are important prognostic factors for OSCC.
KeywordsCarcinoma, squamous cell Survival analysis Mouth neoplasms Prognosis
Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
Conflict of Interest
The authors declare that they have no conflict of interest.
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