, Volume 16, Issue 4, pp 352–361 | Cite as

Evaluation of the efficacy of Hypericum perforatum (St. John’s wort) oil in the prevention of stricture due to esophageal corrosive burns

  • Mustafa Alper AkayEmail author
  • Mustafa Akduman
  • Ahmet Çağrı Tataroğlu
  • Ceyla Eraldemir
  • Tuğba Kum
  • Çiğdem Vural
  • Gülşen Ekingen Yıldız
Original Article



The inflammatory response that follows the caustic burns results in fibrosis on the esophageal wall leading to esophageal stricture, dysphagia, and malnutrition. The controversy over the use of corticosteroids warrants alternative therapeutic interventions. We investigated the effect of extracts from St. John’s wort (SJW) with known wound-healing activity on stricture formation in rat esophageal injury models.


Five experimental groups were involved: sham group with no injury, control group with injury without treatment, and three different treatment groups (methylprednisolone, SJW extract, and combination of the two). Histopathological examination of esophageal damage and collagen accumulation, stenosis index, and tissue hydroxyproline levels were used to assess stricture and the effect of treatments.


There was a significant weight loss in all groups except for those without injury and those treated with SJW extract, the latter gained weight albeit not significant. Stenosis index was increased in all groups compared to sham but not significantly in those treated with SJW extract. Histopathological and biochemical analyses produced mixed results.


Some of the experimental indicators such as weight gain and stenosis index suggested the treatment of esophageal injury models using extracts of St. John’s wort effective while other histopathological indicators show no significant benefit.


Corrosive burns Esophageal stricture St. John’s wort Stenosis 



I want to give special thanks to Prof. Dr. Canan Baydemir (Kocaeli University Faculty of Medicine, Department of Biostatistics) and Dr. Sibel Balcı (Kocaeli University Faculty of Medicine, Department of Biostatistics) for statistical analysis and revisions.


This study was funded by Kocaeli University Scientific Research Project Unit Quick Support Fund.

Compliance with ethical standards

Ethical Statement

All applicable international, national, and institutional guidelines for the care and use of animals were followed. We took ethical approval from Kocaeli University Clinical Research Ethics Committee.

Conflict of interest

Mustafa Alper Akay declares that he has no conflict of interest. Mustafa Akduman declares that he has no conflict of interest. Ahmet Çağrı Tataroğlu declares that he has no conflict of interest. Ceyla Eraldemir declares that she has no conflict of interest. Tuğba Kum declares that she has no conflict of interest. Çiğdem Vural declares that she has no conflict of interest. Gülşen Ekingen Yıldız declares that she has no conflict of interest.

Supplementary material

10388_2019_671_MOESM1_ESM.png (1.4 mb)
Supplementary material 1 (PNG 1443 kb)


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Copyright information

© The Japan Esophageal Society and Springer 2019

Authors and Affiliations

  1. 1.Department of Pediatric SurgeryKocaeli University Medical FacultyKocaeliTurkey
  2. 2.Republic of Turkey Ministry of HealthAnkaraTurkey
  3. 3.Department of BiochemistryKocaeli University Medical FacultyKocaeliTurkey
  4. 4.Department of PathologyKocaeli University Medical FacultyKocaeliTurkey

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