Barrett’s esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects
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Although both eosinophilic esophagitis (EoE) and Barrett’s esophagus (BE) are considered to be associated with T helper (Th) 2-mediated immune responses, the association between EoE and BE is unclear. We investigated the clinical relationship between EoE and BE.
We conducted a single-center retrospective observational study. The study included 95 patients with EoE and randomly selected age- and sex-matched controls who underwent esophagogastroduodenoscopy during a medical health check-up at Osaka City University in a ratio of 1:2 for comparison. We compared the clinical characteristics and the prevalence rate of BE, reflux esophagitis (RE), hiatal hernia, and atrophic gastritis between EoE patients and controls by univariate analysis. Furthermore, we performed multivariate logistic regression analysis to investigate the association of these factors with EoE.
On univariate analysis, the prevalence rate of BE was significantly lower in patients with EoE than in controls (2.1% vs. 13.2%; p = 0.00528). In contrast, the prevalence rate of RE was higher in EoE patients than in controls, but it was not statistically significant (absence and Grades A, B, and C: 74.7%, 18.9%, 5.3%, and 1.1% vs. 83.7%, 12.6%, 3.7%, and 0%; p = 0.193, respectively). Multivariate analysis showed that BE was negatively associated with EoE (odds ratio: 0.132; 95% confidence interval: 0.0302–0.573; p = 0.00686).
BE is negatively associated with EoE in Japanese subjects. The mechanism behind the inverse relationship between EoE and BE should be examined.
KeywordsEosinophilic esophagitis Barrett’s esophagus Peptic esophagitis Esophagus Eosinophils
ST, FT, and YF were involved in study conception and design. ST and FT had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of data analysis. KO and SF acquired the data. ST and FT analyzed and interpreted the data. Drafting of the manuscript was performed by ST and FT. Critical revision of the manuscript for important intellectual content was conducted by ST, FT, KO, SH, YN, NK, KT, HY, TT, SF, TW, and YF. All authors have approved the final draft of this manuscript.
Compliance with ethical standards
This study was conducted in accordance with the Declaration of Helsinki and its amendments. The study protocol was approved by the Ethics Committee of the Osaka City University Graduate School of Medicine (No. 3951).
Conflict of interest
The authors declare no conflict of interests for this article.
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