, Volume 16, Issue 1, pp 98–106 | Cite as

Circumferential distribution and clinical characteristics of esophageal cancer in lower esophagus: differences related to histological subtype

  • Mayumi Okada
  • Norihisa IshimuraEmail author
  • Hironobu Mikami
  • Eiko Okimoto
  • Naoki Oshima
  • Youichi Miyaoka
  • Hirofumi Fujishiro
  • Shunji Ishihara
  • Yoshikazu Kinoshita
Original Article



Esophageal adenocarcinoma (EAC) is frequently found on the right-anterior wall of the distal esophagus in short-segment Barrett’s esophagus (SSBE) patients. However, the endoscopic characteristics of EAC in cases with long-segment BE (LSBE) and squamous cell carcinoma (ESCC) in the lower esophagus remain to be fully evaluated. Here, we determined the circumferential distribution and clinical characteristics of esophageal cancer occurring in the lower esophagus based on histological subtype.


We retrospectively reviewed the medical records of 150 patients with esophageal cancer (ESCC, n = 100; EAC, n = 50) diagnosed at our hospital or a related facility between January 2002 and June 2017, including information regarding endoscopic findings, etiology, and clinical parameters.


Of the 100 patients with ESCC, 28 lesions were located in the lower esophagus, though characteristic circumferential distribution was not seen regardless of location. Those showed a greater frequency of smoking and drinking habit and gastric mucosal atrophy as compared to patients with EAC. Consistent with the previous reports, EAC in SSBE (n = 41) was frequently located on the right-anterior wall. Likewise, EAC at the esophagogastric junction (EGJ) in LSBE was frequently located on the right-anterior wall, while EAC distant from the EGJ showed no characteristic circumferential distribution.


Our results showed no circumferential predilection for ESCC in the lower esophagus, suggesting that development of this type of lesion may be less affected by gastroesophageal reflux. In addition, EAC at the EGJ was frequently found on the right-anterior wall irrespective of BE length.


Barrett’s esophagus Esophageal adenocarcinoma Esophageal cancer Esophageal squamous cell carcinoma 


Compliance with ethical standards

Ethical statement

The present study was performed at the Shimane University Hospital in accordance with the Declaration of Helsinki and the protocol was approved by the ethics committee of the Shimane University School of Medicine.

Conflict of interest

Authors declare no conflict of interests for this article.


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Copyright information

© The Japan Esophageal Society and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Gastroenterology and HepatologyShimane University School of MedicineIzumoJapan
  2. 2.Division of EndoscopyShimane Prefectural Central HospitalIzumoJapan
  3. 3.Division of GastroenterologyShimane Prefectural Central HospitalIzumoJapan

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