Posterior vitreous detachment in patients with diabetes mellitus
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To compare the progression of posterior vitreous detachment (PVD) during aging among eyes of diabetics with diabetic retinopathy (DR), eyes of diabetics without DR, and eyes of nondiabetics.
Prospective cross-sectional study.
One-hundred thirty-three diabetic eyes with DR (DR group), 254 diabetic eyes without DR (non-DR group), and 577 nondiabetic eyes (nondiabetic group) were divided into four age categories: 1) 40-49 years, 2) 50-59 years, 3) 60-69 years, and 4) 70-79 years. The PVD state was examined using swept source-optical coherence tomography and classified into five stages: 0 (non PVD), 1 (paramacular PVD), 2 (perifoveal PVD), 3 (vitreofoveal separation), and 4 (complete PVD).
The PVD stage significantly progressed in the DR, non-DR, and nondiabetic groups (p <0.0001). At 40-49 and 50-59 years, the PVD stage did not differ significantly among the three groups. At 60-69 and 70-79 years, the PVD stage was significantly less progressed in the DR than the non-DR and nondiabetic groups (p ≤0.0027), and did not differ significantly between the non-DR and nondiabetic groups. At 70-79 years, complete PVD was detected in 40.6% of eyes in the DR group, 69.6% in the non-DR group, and 73.5% of eyes in the nondiabetic group.
PVD progresses later in diabetic eyes with DR than in diabetic eyes without DR and nondiabetics eyes at 60 and 70 years of age, suggesting a stronger vitreomacular adhesion in diabetics with DR.
KeywordsDiabetes mellitus Diabetic retinopathy Posterior vitreous detachment Swept source-optical coherence tomography
The authors thank SciTechEdit International (Highlands Ranch, CO, USA) for editorial assistance, and Kozi Yonemoto, PhD (Ryukyu University, Okinawa, Japan) for statistical assistance.
Conflicts of interest
K. Hayashi, None; T. Sato, None; S. Manabe, None; A. Hirata, None; K. Yoshimura, None.
- 8.Gella L, Raman R, Kulothungan V, Sharman T. Prevalence of posterior vitreous detachment in the population with type II diabetes mellitus and its effect on diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study SN-DREAMS report no. 23. Jpn J Ophthalmol. 2012;56:262–7.CrossRefGoogle Scholar
- 13.Diabetic Retinopathy Clinical Research Network Writing Committee, Haller JA, Qin H, Apte RS, Beck RR, Bressler NM, et al. Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction. Ophthalmology. 2010;117:1087–93.Google Scholar
- 23.Hogeboom van Buggenum IM, Polak BC, Reichert-Thoen JW, de Vries-Knoppert WA, van Hinsbergh VW, Tangelder GJ. Angiotensin converting enzyme inhibiting therapy is associated with lower vitreous vascular endothelial growth factor concentrations in patients with proliferative diabetic retinopathy. Diabetologia. 2002;45:203–9.CrossRefGoogle Scholar
- 24.Olk RJ, Lee CM, editors. Diabetic retinopathy: practical management. 2nd ed. Philadelphia: Lippincott; 1993. p. 3–20.Google Scholar