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Japanese Journal of Ophthalmology

, Volume 63, Issue 6, pp 448–456 | Cite as

Clinical characteristics of cuticular drusen in the Japanese population

  • Yoichi SakuradaEmail author
  • Koji Tanaka
  • Akiko Miki
  • Hidetaka Matsumoto
  • Akiyuki Kawamura
  • Ryo Mukai
  • Hideo Akiyama
  • Shigeru Honda
  • Ryusaburo Mori
  • Hiroyuki Iijima
Clinical Investigation
  • 24 Downloads

Abstract

Purpose

To investigate the clinical characteristics of eyes with cuticular drusen in Japanese individuals, while paying special attention to large colloid drusen (LCD).

Study design

Retrospective case series.

Methods

Eyes with cuticular drusen, from patients of 4 medical institutes in Japan, were investigated. Multimodal imaging findings were used to diagnose cuticular drusen. LCD was defined as cuticular drusen > 200 µm.

Results

Twenty-four eyes from 12 patients (8 women, 4 men) were diagnosed with cuticular drusen. The mean age of all patients (n = 12) was 60.8 years. The mean age of patients without additional macular pathology (n = 5) was 55.4 years. Of the 7 patients with additional macular pathology, 6 (85.7%) exhibited age-related macular degeneration-associated macular pathology, including drusenoid pigment epithelial detachment (PED) (8 eyes from 4 patients), geographic atrophy (2 eyes from 1 patient), and occult choroidal neovascularization (1 eye). LCD were found in 6 eyes of 3 patients (25%), those with LCD were on average 53.7 ± 8.7 years old and those without 69.9 ± 14.1 years of age (P = 0.064, Mann–Whitney U test).

Conclusions

Cuticular drusen were predominantly seen in females, and drusenoid PED was most frequently seen in eyes with additional macular pathology. LCD were seen in 25% of eyes with cuticular drusen.

Keywords

Cuticular drusen Age-related macular degeneration Drusenoid pigment epithelial detachment Large colloid drusen 

Notes

Conflicts of interest

Y. Sakurada, Lecture fee (Santen, Novartis, Bayer); K. Tanaka, None; A. Miki, None; H. Matsumoto, None; A. Kawamura, None; R. Mukai, None; H. Akiyama, None; S. Honda, None; R. Mori, None; H. Iijima, Lecture fee (Novartis), Speaker fee (Bayer, Novartis, Santen, Shionogi).

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Copyright information

© Japanese Ophthalmological Society 2019

Authors and Affiliations

  • Yoichi Sakurada
    • 1
    Email author
  • Koji Tanaka
    • 2
  • Akiko Miki
    • 3
  • Hidetaka Matsumoto
    • 4
  • Akiyuki Kawamura
    • 2
  • Ryo Mukai
    • 4
  • Hideo Akiyama
    • 4
  • Shigeru Honda
    • 5
  • Ryusaburo Mori
    • 2
  • Hiroyuki Iijima
    • 1
  1. 1.Department of Ophthalmology, Faculty of MedicineUniversity of YamanashiChuoJapan
  2. 2.Division of Ophthalmology, Department of Visual SciencesNihon University School of MedicineTokyoJapan
  3. 3.Division of Ophthalmology, Department of SurgeryKobe University Graduate School of MedicineHyogoJapan
  4. 4.Department of OphthalmologyGunma University School of MedicineGunmaJapan
  5. 5.Department of Ophthalmology and Visual SciencesOsaka City University, Graduate School of MedicineOsakaJapan

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