Japanese Journal of Ophthalmology

, Volume 63, Issue 4, pp 322–327 | Cite as

Comparison of different combinations of maximum medical therapy for lowering intraocular pressure in primary open angle glaucoma: 12-month retrospective consecutive case series

  • Hee Jung Joh
  • Sang Wook JinEmail author
Clinical Investigation



To compare the efficacy and safety of two combinations of maximum medical therapy for lowering intraocular pressure (IOP) in primary open angle glaucoma (POAG).

Study design

A retrospective consecutive case series.


A retrospective consecutive case series study including 82 eyes of 82 subjects with POAG treated with maximum medical therapy to lower IOP. Enrolled patients were divided into 2 groups: the triple maximum medical therapy (TMT) group, comprising POAG patients who were treated with tafluprost, brimonidine and the fixed drug combination (FDC) brinzolamide/timolol; and the double maximum medical therapy (DMT) group, comprising POAG patients who were treated with the FDCs tafluprost/timolol and brinzolamide/brimonidine. We compared the demographics, baseline IOP, IOP reduction rate, and adverse drug reactions (ADRs) between the 2 groups.


While the mean IOP reduction rate after 12 months was higher in the TMT group (52.7%) than in the DMT group (50.4%), the difference was not significant (p-value = 0.615). In the TMT group, the rate of proceeding to laser or surgical therapy was 22.2% (DMT group = 37.8%). In the TMT group, the time duration between beginning maximum medical therapy and proceeding to laser or surgical therapy was 10.7 ± 1.3 months (DMT group = 10.3 ± 1.5 months). No serious ADRs were reported in either group. However, the incidence rate of conjunctival hyperemia and dry eye was significantly lower in the DMT group than in the TMT group.


DMT is safe and effective for lowering IOP in POAG patients. DMT is not inferior to TMT in POAG patients.


Maximum medical therapy Primary open angle glaucoma Intraocular pressure 



This work was supported by Dong-A University Research Fund. The authors thank American Journal Experts ( for providing editing services for this manuscript.

Conflicts of interest

H. J. Joh, None; S. W. Jin, None.


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Copyright information

© Japanese Ophthalmological Society 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyDong-A University College of MedicineBusanRepublic of Korea

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