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Japanese Journal of Ophthalmology

, Volume 63, Issue 4, pp 304–309 | Cite as

Acute retinal necrosis following herpes simplex encephalitis: a nationwide survey in Japan

  • Daisuke TodokoroEmail author
  • Satoshi Kamei
  • Hiroshi Goto
  • Yoshio Ikeda
  • Hiroshi Koyama
  • Hideo Akiyama
Clinical Investigation
  • 59 Downloads

Abstract

Purpose

Acute retinal necrosis (ARN) is a severe necrotizing retinitis caused by varicella-zoster virus or herpes simplex virus (HSV) that often results in blindness. Occasionally, HSV-caused ARN develops after herpes simplex encephalitis (HSE). It remains unknown, however, when and how often ARN develops after HSE. To investigate the actual conditions of patients with ARN following HSE and the interval period between the prior HSE and the onset of ARN, a retrospective nationwide survey of the Japanese population was performed.

Study design

Retrospective.

Methods

Questionnaires were sent out to the neurology and ophthalmology departments of teaching hospitals in Japan. They inquired about HSE patients in neurology departments and ARN patients diagnosed with HSV in ophthalmology departments. The proportion of the HSV-ARN patients with a history of HSE and their interval periods were obtained from the questionnaires returned by the ophthalmology departments.

Results

Neurology departments of 324 hospitals responded to the questionnaires (response proportion: 40.9%), and 53 HSE cases were reported. Ophthalmology departments of 535 hospitals responded the questionnaires (response proportion: 54.3%), and 67 HSV-ARN cases were reported. Among the 67 HSV-ARN cases, 16 (23.9%) had histories of prior HSE. Although the interval periods from the prior HSE to the onset of HSV-ARN varied among cases, nearly half developed HSV-ARN within 2 years.

Conclusions

This nationwide survey of the Japanese population showed that HSV-ARN develops after HSE in higher frequency within 2 years. Neurologists and ophthalmologists should be aware that HSE survivors have a risk of contracting HSV-ARN.

Keywords:

Acute retinal necrosis Herpes simplex encephalitis Herpes simplex virus 

Notes

Acknowledgements

We would like to thank all of the doctors who responded to our questionnaires, and Ms. Masumi Ishikawa for her assistance with this survey.

Conflicts of interest

D.Todokoro, None; S.Kamei, None; H.Goto, None; Y.Ikeda, None; H.Koyama, None; H.Akiyama, None.

References

  1. 1.
    Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, et al. Diagnosis and treatment of acute retinal necrosis: a report by the American Academy of Ophthalmology. Ophthalmology. 2017;124:382–92.CrossRefGoogle Scholar
  2. 2.
    Shahi SK. Acute retinal necrosis results in low vision in a young patient with a history of herpes simplex virus encephalitis. Clin Exp Optom. 2017;100:208–13.CrossRefGoogle Scholar
  3. 3.
    Zhou C, Zhu L, Fang S. Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: a case report. Exp Ther Med. 2016;12:2227–9.CrossRefGoogle Scholar
  4. 4.
    Arruti M, Aldazabal M, Blanco A, Pineiro L, Zapico MS, Gonzalez F, et al. [Acute herpes simplex virus type 1 retinal necrosis three years after herpes simplex encephalitis]. Rev Neurol. 2014;58:45–6.Google Scholar
  5. 5.
    Sugitani K, Hirano Y, Yasukawa T, Yoshida M, Ogura Y. Unilateral acute retinal necrosis 2 months after herpes simplex encephalitis. Ophthalmic Surg Lasers Imaging. 2010;9:1–5.Google Scholar
  6. 6.
    Patel P, Ahmed E, Subramanian ML. Intravitreal foscarnet therapy for acyclovir-resistant acute retinal necrosis after herpes simplex encephalitis. Ophthalmic Surg Lasers Imaging. 2010;9:1–3.Google Scholar
  7. 7.
    Kianersi F, Masjedi A, Ghanbari H. Acute retinal necrosis after herpetic encephalitis. Case Rep Ophthalmol. 2010;1:85–9.CrossRefGoogle Scholar
  8. 8.
    Vandercam T, Hintzen RQ, de Boer JH, Van der Lelij A. Herpetic encephalitis is a risk factor for acute retinal necrosis. Neurology. 2008;71:1268–74.CrossRefGoogle Scholar
  9. 9.
    Yamamoto S, Nakao T, Kajiyama K. Acute retinal necrosis following herpes simplex encephalitis. Arch Neurol. 2007;64:283.CrossRefGoogle Scholar
  10. 10.
    Klein A, Lefebvre P. Three consecutive episodes of acute retinal necrosis due to herpes simplex-1 over twelve years following herpetic encephalitis. Ocul Immunol Inflamm. 2007;15:411–3.CrossRefGoogle Scholar
  11. 11.
    Curtis TH, Mandava N. Acute retinal necrosis as a late sequela of herpes simplex type 1 encephalitis in a child. J AAPOS. 2007;11:509–10.CrossRefGoogle Scholar
  12. 12.
    Bristow EA, Cottrell DG, Pandit RJ. Bilateral acute retinal necrosis syndrome following herpes simplex type 1 encephalitis. Eye (Lond). 2006;20:1327–30.CrossRefGoogle Scholar
  13. 13.
    Whitley RJ. Herpes simplex encephalitis: adolescents and adults. Antiviral Res. 2006;71:141–8.CrossRefGoogle Scholar
  14. 14.
    Solomon T, Michael BD, Smith PE, Sanderson F, Davies NW, Hart IJ, et al. Management of suspected viral encephalitis in adults–Association of British Neurologists and British Infection Association National Guidelines. J Infect. 2012;64:347–73.CrossRefGoogle Scholar
  15. 15.
    Takase H, Okada AA, Goto H, Mizuki N, Namba K, Ohguro N, et al. Development and validation of new diagnostic criteria for acute retinal necrosis. Jpn J Ophthalmol. 2015;59:14–20.CrossRefGoogle Scholar
  16. 16.
    Kamei S, Takasu T. Nationwide survey of the annual prevalence of viral and other neurological infections in Japanese inpatients. Intern Med. 2000;39:894–900.CrossRefGoogle Scholar
  17. 17.
    Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.CrossRefGoogle Scholar
  18. 18.
    Raschilas F, Wolff M, Delatour F, Chaffaut C, De Broucker T, Chevret S, et al. Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study. Clin Infect Dis. 2002;35:254–60.CrossRefGoogle Scholar
  19. 19.
    Boucher A, Herrmann JL, Morand P, Buzele R, Crabol Y, Stahl JP, et al. Epidemiology of infectious encephalitis causes in 2016. Med Mal Infect. 2017;47:221–35.CrossRefGoogle Scholar
  20. 20.
    Wada-Isoe K, Kusumi M, Kai T, Awaki E, Shimoda M, Yano H, et al. Epidemiological study of acute encephalitis in Tottori Prefecture. Japan. Eur J Neurol. 2008;15:1075–9.CrossRefGoogle Scholar

Copyright information

© Japanese Ophthalmological Society 2019

Authors and Affiliations

  • Daisuke Todokoro
    • 1
    Email author
  • Satoshi Kamei
    • 2
  • Hiroshi Goto
    • 3
  • Yoshio Ikeda
    • 4
  • Hiroshi Koyama
    • 5
  • Hideo Akiyama
    • 1
  1. 1.Department of OphthalmologyGunma University Graduate School of MedicineMaebashiJapan
  2. 2.Division of Neurology, Department of MedicineNihon University School of MedicineItabashiJapan
  3. 3.Department of OphthalmologyTokyo Medical UniversityShinjukuJapan
  4. 4.Department of NeurologyGunma University Graduate School of MedicineMaebashiJapan
  5. 5.Department of Public HealthGunma University Graduate School of MedicineMaebashiJapan

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