Advertisement

Japanese Journal of Ophthalmology

, Volume 63, Issue 1, pp 65–72 | Cite as

Current status of late and recurrent intraocular lens dislocation: analysis of real-world data in Japan

  • Sumihiro Kawano
  • Masato Takeuchi
  • Shiro Tanaka
  • Takehiro Yamashita
  • Taiji Sakamoto
  • Koji KawakamiEmail author
Clinical Investigation
  • 60 Downloads

Abstract

Purpose

To describe relevant patient demographic characteristics and investigate the influence of known risk factors for late intraocular lens (IOL) dislocation. To explore the associations between these risk factors and the incidence of recurrent IOL dislocation.

Study design

Retrospective cohort study.

Methods

This study was performed using Nationwide Diagnostic Procedure Combination data in Japan from April 1, 2008 through July 31, 2016. Descriptive statistics for late and recurrent IOL dislocation, incidence rates, and risk factors for recurrent IOL dislocation were analyzed using a Cox proportional hazard model.

Results

We identified 678 patients with late IOL dislocation. Most were men (72%, 488/678), and the men were younger than their women counterparts (mean age 65.2 years vs. 74.5 years). The incidence rate of recurrent IOL dislocation was 5.1 per 100 person-years. All 20 cases of recurrent IOL dislocation were observed within the year following surgery. There were no significant associations between potential risk factors and recurrent IOL dislocation (adjusted hazard ratio [HR] 1.53, 95% confidence interval [CI] 0.55–4.26 for diabetes mellitus; adjusted HR 0.77, 95%CI 0.09–6.40 for atopic dermatitis); no recurrences occurred in patients with pseudoexfoliation syndrome, retinitis pigmentosa, or connective tissue disease.

Conclusions

Late IOL dislocation occurs more frequently in men. We found that recurrent IOL dislocation was rare during long-term follow-up and there were no significant associations between the potential risk factors and recurrent IOL dislocation. Further studies are needed to clarify the sex-related differences involved in IOL dislocation.

Keywords

Late IOL dislocation Complications Risk factors Recurrent IOL dislocation Epidemiology 

Notes

Acknowledgements

The authors thank Dr. Toshifumi Yamashita for making useful comments on the study design.

Conflicts of interest

S. Kawano, None; M. Takeuchi, None; S. Tanaka, None; T. Yamashita, None; T. Sakamoto, None; K. Kawakami, Consultant fees (Kaken, Kyowa Hakko Kirin, Olympus, Otsuka), Honorarium (Behringer Ingelheim Japan, Daiichi Sankyo, Eisai, Mitsubishi Tanabe Pharma, Novartis, Sanofi, Shionogi, Takeda), Lecture fee (Santen).

References

  1. 1.
    The international agency for the prevention of blindness. https://www.iapb.org/iapb-regions/western-pacific/japan/. Accessed March 13, 2018
  2. 2.
    Gimbel HV, Condon GP, Kohnen T, Olson RJ, Halkiadakis I. Late in-the-bag intraocular lens dislocation: incidence, prevention, and management. J Cataract Refract Surg. 2005;31:2193–204.CrossRefGoogle Scholar
  3. 3.
    Ascaso FJ, Huerva V, Grzybowski A. Epidemiology, Etiology, and Prevention of Late IOL-Capsular Bag Complex Dislocation: Review of the Literature. J Ophthal. 2015;2015:805706.Google Scholar
  4. 4.
    Pueringer SL, Hodge DO, Erie JC. Risk of late intraocular lens dislocation after cataract surgery, 1980–2009: a population-based study. Am J Ophthalmol. 2011;152:618–23.CrossRefGoogle Scholar
  5. 5.
    Monestam EI. Incidence of dislocation of intraocular lenses and pseudophakodonesis 10 years after cataract surgery. Ophthalmology. 2009;116:2315–20.CrossRefGoogle Scholar
  6. 6.
    Dabrowska-Kloda K, Kloda T, Boudiaf S, Jakobsson G, Stenevi U. Incidence and risk factors of late in-the-bag intraocular lens dislocation: Evaluation of 140 eyes between 1992 and 2012. J Cataract Refract Surg. 2015;41:1376–82.CrossRefGoogle Scholar
  7. 7.
    Gross JG, Kokame GT, Weinberg DV. In-the-bag intraocular lens dislocation. Am J Ophthalmol. 2004;137:630–5.Google Scholar
  8. 8.
    Vazquez-Ferreiro P, Carrera-Hueso FJ, Fikri-Benbrahim N, Barreiro-Rodriguez L, Diaz-Rey M, Ramon Barrios MA. Intraocular lens dislocation in pseudoexfoliation: a systematic review and meta-analysis. Acta Ophthalmol. 2017;95:e164–9.CrossRefGoogle Scholar
  9. 9.
    Yamazaki S, Nakamura K, Kurosaka D. Intraocular lens subluxation in a patient with facial atopic dermatitis. J Cataract Refract Surg. 2001;27:337–8.CrossRefGoogle Scholar
  10. 10.
    Bassily R, Lencova A, Rajan MS. Bilateral rupture of the posterior capsule and intraocular lens dislocation from excessive eye rubbing. J Cataract Refract Surg. 2016;42:329–31.CrossRefGoogle Scholar
  11. 11.
    Assia EI, Apple DJ, Morgan RC, Legler UF, Brown SJ. The relationship between the stretching capability of the anterior capsule and zonules. Invest Ophthalmol Vis Sci. 1991;32:2835–9.Google Scholar
  12. 12.
    Fernández-Buenaga R, Alio JL, Pérez-Ardoy AL, Larrosa-Quesada A, Pinilla-Cortés L, Barraquer R, et al. Late in-the-bag intraocular lens dislocation requiring explantation: Risk factors and outcomes. Eye (Basingstoke). 2013;27:795–802.Google Scholar
  13. 13.
    Steeples LR, Jones NP. Late in-the-bag intraocular lens dislocation in patients with uveitis. Br J Ophthalmol. 2015;99:1206–10.CrossRefGoogle Scholar
  14. 14.
    Davis D, Brubaker J, Espandar L, Stringham J, Crandall A, Werner L, et al. Late in-the-bag spontaneous intraocular lens dislocation: evaluation of 86 consecutive cases. Ophthalmology. 2009;116:664–70.CrossRefGoogle Scholar
  15. 15.
    Su WW, Chang SH. Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. J Cataract Refract Surg. 2004;30:1805–7.CrossRefGoogle Scholar
  16. 16.
    Tanaka S, Seto K, Kawakami K. Pharmacoepidemiology in Japan: medical databases and research achievements. J Pharm Health Care Sci. 2015;1:16.CrossRefGoogle Scholar
  17. 17.
    Ishii M. DRG/PPS and DPC/PDPS as prospective payment systems. JMAJ. 2012;55:279–91.Google Scholar
  18. 18.
    Japanese Ministry of Health, Labour and Welfare. The DPC amd preparing hospitals scale. 2016 (in Japanese) http://www.mhlw.go.jp/file/05-Shingikai-12404000-Hokenkyoku-Iryouka/0000121094.pdf. Accessed July 30, 2017.
  19. 19.
    Yamamoto T, Iwase A, Araie M, Suzuki Y, Abe H, Shirato S, et al. The Tajimi Study report 2: prevalence of primary angle closure and secondary glaucoma in a Japanese population. Ophthalmology. 2005;112:1661–9.CrossRefGoogle Scholar
  20. 20.
    Miyazaki M, Kubota T, Kubo M, Kiyohara Y, Iida M, Nose Y, et al. The prevalence of pseudoexfoliation syndrome in a Japanese population: the Hisayama study. J Glaucoma. 2005;14:482–4.CrossRefGoogle Scholar
  21. 21.
    Yardley AM, Ali A, Najm-Tehrani N, Mireskandari K. Refractive and visual outcomes after surgery for pediatric traumatic cataract. J Cataract Refract Surg. 2018;44:85–90.CrossRefGoogle Scholar
  22. 22.
    Kim SS, Smiddy WE, Feuer W, Shi W. Management of dislocated intraocular lenses. Ophthalmology. 2008;115:1699–704.CrossRefGoogle Scholar
  23. 23.
    Yotsukura-Tsutsui E, Koto T, Tsubota K, Ozawa Y. Predisposing factors for intraocular lens dislocation treated by pars plana vitrectomy: Involvement of atopic dermatitis. J Cataract Refract Surg. 2015;41:892–4.CrossRefGoogle Scholar
  24. 24.
    Takeuchi S, Esaki H, Furue M. Epidemiology of atopic dermatitis in Japan. J Dermatol. 2014;41:200–4.CrossRefGoogle Scholar
  25. 25.
    Azuma N, Hida T, Katsura H, Takeuchi S, Danjo S, Tano Y. Retrospective survey of surgical outcomes on rhegmatogenous retinal detachments associated with atopic dermatitis. Arch Ophthalmol. 1996;114:281–5.CrossRefGoogle Scholar
  26. 26.
    Hayashi H, Hayashi K, Nakao F, Hayashi F. Area reduction in the anterior capsule opening in eyes of diabetes mellitus patients. J Cataract Refract Surg. 1998;24:1105–10.CrossRefGoogle Scholar
  27. 27.
    Koike T, Baba T, Nizawa T, Oshitari T, Yamamoto S. Characteristics of patients with spontaneous dislocation of in-the-bag intraocular lens after pars plana vitrectomy. Jpn J Ophthalmol. 2017;61:267–70.CrossRefGoogle Scholar
  28. 28.
    Vote BJ, Tranos P, Bunce C, Charteris DG, Da Cruz L. Long-term outcome of combined pars plana vitrectomy and scleral fixated sutured posterior chamber intraocular lens implantation. Am J Ophthalmol. 2006;141:308–12.CrossRefGoogle Scholar
  29. 29.
    Bading G, Hillenkamp J, Sachs HG, Gabel VP, Framme C. Long-term safety and functional outcome of combined pars plana vitrectomy and scleral-fixated sutured posterior chamber lens implantation. Am J Ophthalmol. 2007;144:371–7.CrossRefGoogle Scholar
  30. 30.
    Hayashi K, Hirata A, Hayashi H. Possible predisposing factors for in-the-bag and out-of-the-bag intraocular lens dislocation and outcomes of intraocular lens exchange surgery. Ophthalmology. 2007;114:969–75.CrossRefGoogle Scholar
  31. 31.
    Hayashi K, Ogawa S, Manabe S, Hirata A, Yoshimura K. A classification system of intraocular lens dislocation sites under operating microscopy, and the surgical techniques and outcomes of exchange surgery. Graefes Arch Clin Exp Ophthalmol. 2016;254:505–13.CrossRefGoogle Scholar
  32. 32.
    Yamana H, Moriwaki M, Horiguchi H, Kodan M, Fushimi K, Yasunaga H. Validity of diagnoses, procedures, and laboratory data in Japanese administrative data. J Epidemiol. 2017;27:476–82.CrossRefGoogle Scholar
  33. 33.
    Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.CrossRefGoogle Scholar
  34. 34.
    Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:613–9.CrossRefGoogle Scholar
  35. 35.
    Wagoner MD, Cox TA, Ariyasu RG, Jacobs DS, Karp CL. Intraocular lens implantation in the absence of capsular support. Ophthalmology. 2003;110:840–59.CrossRefGoogle Scholar
  36. 36.
    Gabor SG, Pavlidis MM. Sutureless intrascleral posterior chamber intraocular lens fixation. J Cataract Refract Surg. 2007;33:1851–4.  https://doi.org/10.1016/j.jcrs.2007.07.013.CrossRefGoogle Scholar
  37. 37.
    Maggi R, Maggi C. Sutureless scleral fixation of intraocular lenses. J Cataract Refract Surg. 1997;23:1289–94.CrossRefGoogle Scholar
  38. 38.
    Ohta T, Toshida H, Murakami A. Simplified and safe method of sutureless intrascleral posterior chamber intraocular lens fixation: Y-fixation technique. J Cataract Refract Surg. 2014;40:2–7.CrossRefGoogle Scholar
  39. 39.
    Jakobsson G, Zetterberg M, Lundstrom M, Stenevi U, Grenmark R, Sundelin K. Late dislocation of in-the-bag and out-of-the bag intraocular lenses: ocular and surgical characteristics and time to lens repositioning. J Cataract Refract Surg. 2010;36:1637–44.CrossRefGoogle Scholar
  40. 40.
    Krepste L, Kuzmiene L, Miliauskas A, Januleviciene I. Possible predisposing factors for late intraocular lens dislocation after routine cataract surgery. Medicina (Kaunas, Lithuania). 2013;49:229–34.Google Scholar

Copyright information

© Japanese Ophthalmological Society 2018

Authors and Affiliations

  • Sumihiro Kawano
    • 1
    • 2
  • Masato Takeuchi
    • 2
  • Shiro Tanaka
    • 3
  • Takehiro Yamashita
    • 1
  • Taiji Sakamoto
    • 1
  • Koji Kawakami
    • 2
    Email author
  1. 1.Department of OphthalmologyKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan
  2. 2.Department of Pharmacoepidemiology, Graduate School of Medicine and Public HealthKyoto UniversityKyotoJapan
  3. 3.Department of Clinical Biostatistics, Graduate School of MedicineKyoto UniversityKyotoJapan

Personalised recommendations