Facile Synthesis of Boronate Affinity-Based Molecularly Imprinted Monolith with Reduced Capturing pH Towards Cis-Diol-Containing Compounds
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Here, we report a novel boronate affinity-based surface molecularly imprinted monolith (BA-SMIM), which was fabricated by simple two-step atom-transfer radical polymerization (ATRP) strategy. A boronate affinity-based surface non-imprinted monolith (BA-SNIM) was prepared as control. The synthesis parameters of BA-SMIM were optimized, and the resultant BA-SMIM was characterized in detailed. In both aqueous-rich and organic-rich mobile phases, the BA-SMIM could recognize cis-diol-containing compounds mainly due to the imprinting effect. The chlorogenic acid and rosmarinic acid with two cis-diols could interact synergistically with two imprinting cavities of BA-SMIM, so they retained longer on BA-SMIM than one cis-diol-containing compounds. In addition, the capturing pH reduced from 8.6 on BA-SNIM and to 7.8 on BA-SMIM for one cis-diol-containing compounds, and from 7.4 on BA-SNIM and to 7.0 on BA-SMIM for two cis-diol-containing compounds, respectively. The reducing of capturing pH value on BA-SMIM may be attributed to the nanoconfinement effect of imprinting cavity.
KeywordsBoronate affinity Molecularly imprinting polymers Nanoconfinement effect
This work was financially supported by the National Natural Science Foundation of China (Grant No. 21605114), China Postdoctoral Science Foundation (Grant Nos. 2015T80226, 2014M550149) and Tianjin Natural Science Foundation (Grant Nos. 16JCQNJC05500, 17JCQNJC13300).
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Conflict of interest
The authors declare that they have no conflict of interest.
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