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Chromatographia

, Volume 82, Issue 7, pp 1029–1040 | Cite as

Facile Synthesis of Boronate Affinity-Based Molecularly Imprinted Monolith with Reduced Capturing pH Towards Cis-Diol-Containing Compounds

  • Chao Peng
  • Yao-Han Lan
  • Lu Sun
  • Xin-Zhu Chen
  • Shuai-Shuai Chi
  • Chao Zheng
  • Lin-Yi DongEmail author
  • Xian-Hua WangEmail author
Original
  • 36 Downloads

Abstract

Here, we report a novel boronate affinity-based surface molecularly imprinted monolith (BA-SMIM), which was fabricated by simple two-step atom-transfer radical polymerization (ATRP) strategy. A boronate affinity-based surface non-imprinted monolith (BA-SNIM) was prepared as control. The synthesis parameters of BA-SMIM were optimized, and the resultant BA-SMIM was characterized in detailed. In both aqueous-rich and organic-rich mobile phases, the BA-SMIM could recognize cis-diol-containing compounds mainly due to the imprinting effect. The chlorogenic acid and rosmarinic acid with two cis-diols could interact synergistically with two imprinting cavities of BA-SMIM, so they retained longer on BA-SMIM than one cis-diol-containing compounds. In addition, the capturing pH reduced from 8.6 on BA-SNIM and to 7.8 on BA-SMIM for one cis-diol-containing compounds, and from 7.4 on BA-SNIM and to 7.0 on BA-SMIM for two cis-diol-containing compounds, respectively. The reducing of capturing pH value on BA-SMIM may be attributed to the nanoconfinement effect of imprinting cavity.

Keywords

Boronate affinity Molecularly imprinting polymers Nanoconfinement effect 

Notes

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Grant No. 21605114), China Postdoctoral Science Foundation (Grant Nos. 2015T80226, 2014M550149) and Tianjin Natural Science Foundation (Grant Nos. 16JCQNJC05500, 17JCQNJC13300).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10337_2019_3736_MOESM1_ESM.doc (1008 kb)
Supplementary material 1 (DOC 1008 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of PharmacyTianjin Medical UniversityTianjinPeople’s Republic of China
  2. 2.Building B for School of PharmacyTianjin Medical UniversityTianjinPeople’s Republic of China

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