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Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality

  • Michael Pedersen
  • Stephan Ursprung
  • Jens Dam Jensen
  • Bente Jespersen
  • Ferdia Gallagher
  • Christoffer LaustsenEmail author
Review

Abstract

Magnetic resonance imaging (MRI) is a well-established modality for assessing renal morphology and function, as well as changes that occur during disease. However, the significant metabolic changes associated with renal disease are more challenging to assess with MRI. Hyperpolarized carbon-13 MRI is an emerging technique which provides an opportunity to probe metabolic alterations at high sensitivity by providing an increase in the signal-to-noise ratio of 20,000-fold or more. This review will highlight the current status of hyperpolarised 13C-MRI and its translation into the clinic and how it compares to metabolic measurements provided by competing technologies such as positron emission tomography (PET).

Keywords

Renal Kidney Metabolism Hyperpolarisation MRI 

Notes

Funding

This study was funded by Aarhus University Research Foundation and Karen Elise Jensen Foundation.

Compliance with ethical standards

Conflict of interest

CL, SU, MP, BJ, JDJ, and FG declare no conflict of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Copyright information

© European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 2019

Authors and Affiliations

  1. 1.Comparative Medicine LabAarhus UniversityAarhusDenmark
  2. 2.Department of RadiologyUniversity of Cambridge, Addenbrooke’s HospitalCambridgeUK
  3. 3.Department of Renal MedicineAarhus University HospitalAarhusDenmark
  4. 4.MR Research Centre, Department of Clinical MedicineAarhus University Hospital, Palle Juul Jensens BoulevardAarhus NDenmark

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