Quantification of sodium T1 in abdominal tissues at 3 T
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Although relevant for assessment of sodium in multiple endocrine pathways, 23Na-T1 quantification is challenging due to technical limitations (SAR, B1 inhomogeneity) or influence of tissue’s local molecular dynamics. Hereby, we propose T1 quantification of 23Na-MRI signal acquired over the abdomen using a centric-reordered saturation-recovery (SR) true fast imaging with steady state precession (TrueFISP) sequence.
Materials and methods
Measurements were performed at 3T using a dual-tunable 23Na/1H coil in 7 healthy volunteers (TR/TE = 858–928/1.57 ms; flip angle = 90°; bandwidth = 450 Hz/px; voxel size = 5 × 5 × 10 mm3). Variable T1-weighting was achieved applying non-selective saturation pre-pulses delayed from the centre of the k-space acquisition by 25, 40, 60, 120 and 250 ms. T1-curve fitting was performed slice-wise, separately for average intensity values from the manually segmented areas of the renal parenchyma and spinal canal, over the increasing SR times- assuming monoexponential signal pattern.
Mean ± standard deviation of 23Na-T1 was found as 29 ± 10 ms and 35 ± 8 ms for the renal parenchyma and the spinal canal, respectively.
23Na-T1 quantification using a SR-TrueFISP is feasible in clinical settings, in the images constrained by clinically applicable acquisition time of reduced spatial resolution or averages.
Keywords23Na Clinical MRI Sodium T1 3D SR-TrueFISP
We would like to thank Dr. Markus Klarhoefer from Siemens Healthcare AG for his support during protocol optimization. We are also grateful to Dr. Anton S. Becker and to Prof. Dr. Andreas Boss for the application for ethical approval.
RSG—study design, acquisition of data, analysis and interpretation of data, drafting and revision of manuscript;AC—study design, critical revision;AM—study design, critical revision;CR—study conception and design, acquisition of data, drafting of manuscript, critical revision.
This work was supported by the Clinical Research Priority Program of the University of Zurich for the CRPP Hypertension Research Network (HYRENE).
Compliance with ethical standards
Conflict of interest
Authors declare no conflict of interest during research, preparation and submission of current paper.
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