Phase-contrast magnetic resonance imaging for analyzing hemodynamic parameters and wall shear stress of pulmonary arteries in patients with pulmonary arterial hypertension
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To investigate flow-related parameters in pulmonary arteries of patients with pulmonary arterial hypertension (PAH).
Materials and methods
Eleven PAH patients and twelve control participants were recruited. PAH and controls had similar age and gender distribution. 2D phase-contrast MRI (PC-MRI) was performed in the main, right, and left pulmonary artery (MPA, RPA, and LPA). The flow velocity, wall shear stress (WSS), and oscillatory shear index (OSI) were measured.
PAH patients displayed prolonged acceleration time (Tacce) and increased ratio of flow change to acceleration volume in pulmonary arteries (both P < 0.001). The temporally averaged WSS values of MPA, RPA, and LPA in PAH patients were significantly lower than those of control participants (P < 0.001). The OSI in the pulmonary arteries was higher in PAH patients than control participants (P < 0.05). The ROC analysis indicated the ratio of maximum flow change to acceleration volume, WSS, and Tacce exhibited sufficient sensitivity and specificity to detect patients with PAH. The WSS demonstrated strong correlations with Tacce and the ratio value in the two groups (R2 = 0.78–0.96).
We used a clinically feasible 2D PC-MRI sequence with a reasonable scanning time to compute aforementioned indices. The quantitative parameters provided sufficient information to differentiate PAH patients from control participants.
KeywordsPulmonary arterial hypertension Magnetic resonance imaging Flow velocity Wall shear stress
This study was funded by the National Science Council, Taiwan (NSC 102-2320-B-007-003-MY3; MOST 106-2314-B-007-006-MY3) and Veterans General Hospitals and University System of Taiwan Joint Research Program (VGHUST103-G3-1-1).
This study was funded by the Ministry of Science and Technology, Taiwan (NSC 102-2320-B-007-003-MY3; MOST 106-2314-B-007-006-MY3) and Veterans General Hospitals and University System of Taiwan Joint Research Program (VGHUST103-G3-1-1).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent was obtained from all individual participants included in the study.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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