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Phase-contrast magnetic resonance imaging for analyzing hemodynamic parameters and wall shear stress of pulmonary arteries in patients with pulmonary arterial hypertension

  • Hung-Hsuan Wang
  • Wen-Yih Isaac Tseng
  • Hsi-Yu Yu
  • Meng-Chu Chang
  • Hsu-Hsia PengEmail author
Research article
  • 104 Downloads

Abstract

Objective

To investigate flow-related parameters in pulmonary arteries of patients with pulmonary arterial hypertension (PAH).

Materials and methods

Eleven PAH patients and twelve control participants were recruited. PAH and controls had similar age and gender distribution. 2D phase-contrast MRI (PC-MRI) was performed in the main, right, and left pulmonary artery (MPA, RPA, and LPA). The flow velocity, wall shear stress (WSS), and oscillatory shear index (OSI) were measured.

Results

PAH patients displayed prolonged acceleration time (Tacce) and increased ratio of flow change to acceleration volume in pulmonary arteries (both P < 0.001). The temporally averaged WSS values of MPA, RPA, and LPA in PAH patients were significantly lower than those of control participants (P < 0.001). The OSI in the pulmonary arteries was higher in PAH patients than control participants (P < 0.05). The ROC analysis indicated the ratio of maximum flow change to acceleration volume, WSS, and Tacce exhibited sufficient sensitivity and specificity to detect patients with PAH. The WSS demonstrated strong correlations with Tacce and the ratio value in the two groups (R2 = 0.78–0.96).

Conclusions

We used a clinically feasible 2D PC-MRI sequence with a reasonable scanning time to compute aforementioned indices. The quantitative parameters provided sufficient information to differentiate PAH patients from control participants.

Keywords

Pulmonary arterial hypertension Magnetic resonance imaging Flow velocity Wall shear stress 

Notes

Acknowledgements

This study was funded by the National Science Council, Taiwan (NSC 102-2320-B-007-003-MY3; MOST 106-2314-B-007-006-MY3) and Veterans General Hospitals and University System of Taiwan Joint Research Program (VGHUST103-G3-1-1).

Funding

This study was funded by the Ministry of Science and Technology, Taiwan (NSC 102-2320-B-007-003-MY3; MOST 106-2314-B-007-006-MY3) and Veterans General Hospitals and University System of Taiwan Joint Research Program (VGHUST103-G3-1-1).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

10334_2019_767_MOESM1_ESM.tif (731 kb)
Supplementary material 1 (TIF 731 kb)

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Copyright information

© European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 2019

Authors and Affiliations

  1. 1.Department of Biomedical Engineering and Environmental SciencesNational Tsing Hua UniversityHsinchuTaiwan
  2. 2.Institute of Medical Device and Imaging, College of MedicineNational Taiwan UniversityTaipeiTaiwan
  3. 3.Department of SurgeryNational Taiwan University HospitalTaipeiTaiwan

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