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Nanocarrier-mediated co-delivery systems for lung cancer therapy: recent developments and prospects

  • Muhammad Asim Farooq
  • Md Aquib
  • Daulat Haleem Khan
  • Sana Ghayas
  • Anam Ahsan
  • Muhammad Ijaz
  • Parikshit Banerjee
  • Maqsood Ahmed Khan
  • Muhammad Masood Ahmad
  • Bo WangEmail author
Review

Abstract

Research has recently focused on combinational therapy using nanocarriers to overcome the obstacles associated with conventional therapy of lung cancer. The classical therapeutic approach is indeed insufficient for suppressing tumor growth. Simultaneous delivery improves therapeutic outcomes, synergistic effects, and targeting moiety. Besides, multidrug-loaded nanocarriers allows the consecutive release of two or more drugs and genes. A such nanodrug delivery system reduces drug–drug interactions and improves the pharmacokinetics profile of loaded drugs. Currently, nanotechnology-based co-delivery system is the only suitable option for lung cancer therapy. Combinational delivery systems show promising results for the treatment of lung cancer. Here we review the design and development of co-delivery systems based on nanocarriers for effective cancer treatment.

Keywords

Polymeric nanoparticles Lung cancer Micelles Drug delivery systems 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Muhammad Asim Farooq
    • 1
  • Md Aquib
    • 1
  • Daulat Haleem Khan
    • 2
  • Sana Ghayas
    • 3
  • Anam Ahsan
    • 4
  • Muhammad Ijaz
    • 5
  • Parikshit Banerjee
    • 6
  • Maqsood Ahmed Khan
    • 7
  • Muhammad Masood Ahmad
    • 8
  • Bo Wang
    • 1
    Email author
  1. 1.Department of Pharmaceutics, School of PharmacyChina Pharmaceutical UniversityNanjingPeople’s Republic of China
  2. 2.Department of PharmacyLahore College of Pharmaceutical SciencesLahorePakistan
  3. 3.Dow College of PharmacyDow University of Health SciencesKarachiPakistan
  4. 4.College of Animal Science and Veterinary MedicineShanxi Agriculture UniversityJinzhongPeople’s Republic of China
  5. 5.Department of PharmacyCOMSATS UniversityIslamabadPakistan
  6. 6.Department of Medicinal and Applied Chemistry, College of Life ScienceKaohsiung Medical UniversityKaohsiungTaiwan
  7. 7.Department of Pharmaceutics, Faculty of PharmacyZiauddin UniversityKarachiPakistan
  8. 8.Department of Pharmaceutics, College of PharmacyJouf University SakakaSakakaKingdom of Saudi Arabia

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