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Environmental Chemistry Letters

, Volume 17, Issue 3, pp 1209–1223 | Cite as

Drug delivery systems using pullulan, a biocompatible polysaccharide produced by fungal fermentation of starch

  • Anca Giorgiana GrigorasEmail author
Review
  • 276 Downloads

Abstract

Advanced drug delivery systems are now designed with biodegradable, biocompatible and non-toxic materials such as polysaccharides. Pullulan is a polysaccharide consisting of maltotriose units. Pullulan is produced from starch by the fungus Aureobasidium pullulans. Pullulan and derivatives are able to conjugate or complex with hydrophobic drugs. Scientists are optimizing the physical interactions and hydrophilic–hydrophobic balance to create systems with controlled loading and targeted delivery of the drugs to cancer cells or liver cell receptors. This article reviews pullulan-based systems of various therapeutic properties. Pullulan structure can be easily modified to transfer various drugs. Pullulan can form microparticles, nanoparticles, micelles, films and hydrogels. Therapeutic properties include antibacterial, antifungal, antitumor, anti-inflammatory, immunomodulatory, antioxidant, antiglycemic, antilipidemic, bone regenerator and systemic protective role. The medical suitability of pullulan-based drug carriers is confirmed by profiles of drug release and cytotoxicity tests carried out in vivo or in vitro.

Keywords

Pullulan Drug delivery systems Pharmaceutical formulations Therapeutic properties Antimicrobial Antitumor 

Notes

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Laboratory of Natural Polymers, Bioactive and Biocompatible Materials“Petru Poni” Institute of Macromolecular ChemistryIassyRomania

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