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Treatment in epileptic encephalopathy with ESES and Landau–Kleffner syndrome

  • Floor E. JansenEmail author
  • Bart van den Munckhof
Leitthema
  • 12 Downloads

Abstract

Epileptic encephalopathy with electrical status epilepticus in sleep (ESES) is an age-related syndrome with acquired neurodevelopmental deficits in relation to epilepsy with many seizure types. Early and accurate treatment is aimed at prevention or reduction of associated cognitive deficits and, to a lesser extent, control seizures. Evidence for an optimal treatment strategy is still lacking. Here, we review the current literature on treatment efficacy in patients with epileptic encephalopathy with ESES.

Keywords

Epileptic encephalopathy with ESES Cognition Treatment efficacy Corticosteroids Review 

Behandlung bei epileptischer Enzephalopathie mit ESES und Landau-Kleffner Syndrom

Zusammenfassung

Die epileptische Enzephalopathie mit elektrischem Status epilepticus im Schlaf (ESES) ist ein altersabhängiges Syndrom, bei dem es zu erworbenen neurologischen Entwicklungsdefiziten im Zusammenhang mit der Epilepsie und ihren vielen Anfallstypen kommt. Eine frühe und gezielte Therapie wird angestrebt, um die mit dem Syndrom einhergehenden kognitiven Defizite zu verhindern oder zu reduzieren und – in geringerem Maße – Anfälle zu beherrschen. Belege für eine optimale Behandlungsstrategie stehen noch aus. In der vorliegenden Arbeit eine Auswertung der aktuellen Literatur in Bezug auf die Therapiewirksamkeit bei Patienten mit epileptischer Enzephalopathie und ESES dargestellt.

Schlüsselwörter

Epileptische Enzephalopathie mit ESES Kognition Therapiewirksamkeit Kortikosteroide Übersicht 

Notes

Compliance with ethical guidelines

Conflict of interest

F.E. Jansen and B. van den Munckhof declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Child Neurology, Brain Center Rudolf MagnusUniversity Medical Center UtrechtUtrechtThe Netherlands

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