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Vitamin D in der Reproduktionsmedizin

  • Stephan H. ScharlaEmail author
Leitthema
  • 7 Downloads

Zusammenfassung

Hintergrund

Experimentelle Daten belegen den Einfluss von 1,25-Dihydroxy-Vitamin D3 auf die Reproduktionsorgane. Beobachtungsstudien weisen auf eine verminderte Fertilität bei Vitamin-D-Mangel hin.

Fragestellung

Einfluss von Vitamin D auf die Fertilität und Schwangerschaftsrate.

Material und Methoden

Auswertung von Originalarbeiten, Übersichtsarbeiten und Metaanalysen, Diskussion der Ergebnisse.

Ergebnisse

Die Beobachtungsstudien liefern kontroverse Ergebnisse hinsichtlich des Zusammenhangs zwischen Vitamin-D-Status und Fertilität. Gute kontrollierte Studien fehlen. Der Effekt einer Vitamin-D-Supplementation auf die metabolischen Veränderungen beim Syndrom polyzystischer Ovarien ist eher schwach.

Schlussfolgerung

Die Evidenz für eine Supplementation gesunder Frauen mit Vitamin D erscheint schwach. Ein Vitamin-D-Mangel sollte allerdings ausgeglichen werden.

Schlüsselwörter

Syndrom polyzystischer Ovarien Fertilität Vitamin-D-Mangel Schwangerschaftsrate Endometrium 

Vitamin D in reproductive medicine

Abstract

Background

Experimental data give evidence that 1,25-dihydroxy vitamin D3 modulates the function of reproductive organs. Observational studies suggest that vitamin D deficiency is associated with reduced fertility.

Objectives

Influence of vitamin D on fertility and pregnancy rate.

Methods

Analysis of original studies, reviews, and meta-analyses.

Results

Observational studies show controversial results regarding the association between vitamin D status and fertility. Good randomized trials are missing. The effect of vitamin D supplementation on metabolic disturbances in polycystic ovary syndrome is weak.

Conclusion

The evidence for vitamin D supplementation in healthy women is weak. However, a vitamin D deficiency should be corrected.

Keywords

Polycystic ovary syndrome Fertility Vitamin D deficiency Pregnancy rate Endometrium 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

S.H. Scharla gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  1. 1.Praxis für Innere Medizin und Endokrinologie/DiabetologieBad ReichenhallDeutschland

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