Advertisement

Response to: Human papillomavirus (HPV) vaccine safety concerning POTS, CRPS and related conditions

  • Alexandru BarboiEmail author
  • Christopher H. Gibbons
  • Eduardo E. Bennaroch
  • Italo Biaggioni
  • Mark W. Chapleau
  • Gisela Chelimsky
  • Thomas Chelimsky
  • William P. Cheshire
  • Victoria E. Claydon
  • Roy Freeman
  • David S. Goldstein
  • Michael J. Joyner
  • Horacio Kaufmann
  • Phillip A. Low
  • Lucy Norcliffe-Kaufmann
  • David Robertson
  • Cyndya A. Shibao
  • Wolfgang Singer
  • Howard Snapper
  • Steven Vernino
  • Satish R. Raj
  • the American Autonomic Society
Letter to the Editor
  • 63 Downloads

Dear Editors,

We would like to thank Dr. Blitshteyn for her comments on the American Autonomic Society (AAS) statement on the relationship between human papillomavirus vaccine and autonomic disorder [1, 2]. Dr. Blitshteyn has highlighted that the case reports were not written to create an environment of fear and not meant to cause a reduction in vaccination rates. It was not the intent of the AAS statement to suggest that the case report authors were attempting to cause panic; however, the media reports on the complications associated with these small case reports have definitely resulted in a biased public perception of vaccinations. This has further resulted in an environment of fear, intentional or not, and caused a reduction in vaccination rates in many countries, and in some countries the HPV vaccine has been withdrawn [1, 3].

The Skufca Study in Finland did provide valuable information on the incidence of POTS in a general population pre-vaccine [4]. This was followed by a...

Notes

Funding

None.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interest.

References

  1. 1.
    Barboi A, Gibbons CH, Axelrod F et al (2019) Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Clin Auton Res.  https://doi.org/10.1007/s10286-019-00608-w CrossRefPubMedGoogle Scholar
  2. 2.
    Blitshteyn S (2020) Human papillomavirus (HPV) vaccines safety concerning POTS, CRPS and related conditions. Clin Auton Res.  https://doi.org/10.1007/s10286-019-00653-5 CrossRefGoogle Scholar
  3. 3.
    Butts BN, Fischer PR, Mack KJ (2017) Human papillomavirus vaccine and postural orthostatic tachycardia syndrome: a review of current literature. J Child Neurol 32:956–965CrossRefGoogle Scholar
  4. 4.
    Skufca J, Ollgren J, Ruokokoski E, Lyytikainen O, Nohynek H (2017) Incidence rates of Guillain Barre (GBS), chronic fatigue/systemic exertion intolerance disease (CFS/SEID) and postural orthostatic tachycardia syndrome (POTS) prior to introduction of human papilloma virus (HPV) vaccination among adolescent girls in Finland, 2002–2012. Papillomavirus Res 3:91–96CrossRefGoogle Scholar
  5. 5.
    Skufca J, Ollgren J, Artama M, Ruokokoski E, Nohynek H, Palmu AA (2018) The association of adverse events with bivalent human papilloma virus vaccination: a nationwide register-based cohort study in Finland. Vaccine 36:5926–5933CrossRefGoogle Scholar
  6. 6.
    Chandler RE, Juhlin K, Fransson J, Caster O, Edwards IR, Noren GN (2017) Current safety concerns with human papillomavirus vaccine: a cluster analysis of reports in VigiBase((R)). Drug Saf 40:81–90CrossRefGoogle Scholar
  7. 7.
    European Medicines Agency (2015) Assessment report: review under Article 20 of Regulation (EC) No 726/2004. Human papillomavirus (HPV) vaccines. Pharmacovigilance Risk Assessment Committee (PRAC), EMA/762033/2015Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Alexandru Barboi
    • 1
    • 14
    • 20
    Email author
  • Christopher H. Gibbons
    • 2
    • 14
  • Eduardo E. Bennaroch
    • 4
    • 14
  • Italo Biaggioni
    • 5
    • 14
  • Mark W. Chapleau
    • 6
    • 7
    • 8
    • 14
  • Gisela Chelimsky
    • 9
    • 14
  • Thomas Chelimsky
    • 10
    • 14
  • William P. Cheshire
    • 11
    • 14
  • Victoria E. Claydon
    • 12
    • 14
  • Roy Freeman
    • 2
    • 14
  • David S. Goldstein
    • 13
    • 14
  • Michael J. Joyner
    • 2
    • 14
  • Horacio Kaufmann
    • 3
    • 14
  • Phillip A. Low
    • 4
    • 14
  • Lucy Norcliffe-Kaufmann
    • 14
    • 15
    • 16
  • David Robertson
    • 5
    • 14
  • Cyndya A. Shibao
    • 5
    • 14
  • Wolfgang Singer
    • 4
    • 14
  • Howard Snapper
    • 14
    • 17
  • Steven Vernino
    • 14
    • 18
  • Satish R. Raj
    • 5
    • 14
    • 19
  • the American Autonomic Society
  1. 1.Department of Neurology, NorthShore University Health System, Pritzker School of MedicineUniversity of ChicagoChicagoUSA
  2. 2.Department of Neurology, Beth Israel Deaconess Medical CenterHarvard UniversityBostonUSA
  3. 3.Department of NeurologyNew York UniversityNew YorkUSA
  4. 4.Department of NeurologyMayo ClinicRochesterUSA
  5. 5.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction CenterVanderbilt University School of MedicineNashvilleUSA
  6. 6.Department of MedicineUniversity of IowaIowaUSA
  7. 7.Department of Molecular PhysiologyUniversity of IowaIowaUSA
  8. 8.Department of BiophysicsUniversity of IowaIowaUSA
  9. 9.Department of PediatricsMedical College of WisconsinMilwaukeeUSA
  10. 10.Department of NeurologyMedical College of WisconsinMilwaukeeUSA
  11. 11.Department of NeurologyMayo ClinicJacksonvilleUSA
  12. 12.Department of Biomedical Physiology and KinesiologySimon Fraser UniversityBurnabyCanada
  13. 13.Autonomic Medicine SectionNational Institute of Neurological, Diseases and Stroke, National Institutes of HealthBethesdaUSA
  14. 14.Department of Anesthesia and Perioperative MedicineMayo ClinicRochesterUSA
  15. 15.Department of PhysiologyNew York UniversityNew YorkUSA
  16. 16.Department of NeurosciencesNew York UniversityNew YorkUSA
  17. 17.Cardiology DivisionWellstar Healthcare SystemAtlantaUSA
  18. 18.Department of Neurology and NeurotherapeuticsUT Southwestern Medical CenterDallasUSA
  19. 19.Department of Cardiac Sciences, Libin Cardiovascular Institute of AlbertaUniversity of CalgaryCalgaryCanada
  20. 20.American Autonomic SocietyLa JollaUSA

Personalised recommendations