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Odontology

, Volume 107, Issue 4, pp 457–464 | Cite as

Effects of metabolic syndrome on jawbones and bone metabolic markers in sucrose-fed rats

  • Hüseyin Can TükelEmail author
  • Ertan Delilbaşı
Original Article

Abstract

The aim of this study was to investigate the effects of metabolic syndrome (MetS) on bone mineral density (BMD) and microstructure of jawbones, and circulating bone metabolic markers. MetS was induced in male Wistar rats by a 16-week high-sucrose drinking water diet. Mandibles were analyzed for BMD and microstructure by standard radiographs and X-ray diffraction. BMD of three different regions of mandible in MetS group was significantly lower compared to control group. The diffraction intensity of mandibular bone in MetS group was significantly decreased (8.2%) compared to control group; however, crystallite radiuses of mandibular bone samples in both groups were not significantly different. In MetS group, serum bone-specific tartrate-resistant acid phosphatase-5b (TRACP-5b) activity was significantly increased (47%), whereas bone-specific alkaline phosphatase (BALP) activity was significantly decreased (44%) compared to control group. The serum magnesium level in MetS rats (1.82 ± 0.27 mg dL−1) was lower than that of controls (2.11 ± 0.16 mg dL−1). Rats with MetS had significantly higher serum calcium level (9.70 ± 0.41 mg dL−1) than the controls (9.21 ± 0.50 mg dL−1). Overall data suggested that MetS is associated with a significant decrease in BMD and slight deterioration in microcrystallite structure of the jawbones. The changes in TRACP-5b and BALP activities and serum Ca2+ and Mg2+ concentrations also support these findings at a biochemical level.

Keywords

Mandible Metabolic syndrome Bone mineral density Bone-specific tartrate-resistant acid phosphatase-5b Sucrose 

Notes

Acknowledgements

We would like to thank Dr. Esma N. Okatan for her help with the animal handling and we would like to thank Begum Selen Uzun for her help with statistical analysis. The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© The Society of The Nippon Dental University 2019

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial Surgery, Faculty of DentistryÇukurova UniversityAdanaTurkey
  2. 2.Department of Oral and Maxillofacial Surgery, Faculty of DentistryGazi UniversityAnkaraTurkey

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