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The prognostic role of CD133 expression in patients with osteosarcoma


Osteosarcoma (OS), a malignant bone tumor, mainly occurs in adolescents. Cluster of differentiation 133 (CD133) is one of the most common tumor stem cell biomarkers. The prognostic significance of CD133 in OS has been reported, while the conclusions of these study were inconsistent. This study was conducted to investigate the association between CD133 expression and OS. We performed a search using several database including NCBI PubMed, Springer, CNKI, Web of Science and Wanfang for relevant papers about the prognostic value of CD133 on OS published before October 19, 2019. Pooled odds ratio (OR) and 95% CI were used to evaluate the outcomes. Seven reports including 498 OS patients were used for evaluating the association between CD133 positive expression and OS clinicopathological features. CD133 positive expression was not related to the age, gender, tumor size, tumor location and pathological type of OS. The expression of CD133 was significantly associated with high ennecking stage of OS (OR 9.67, 95% CI 5.56–16.80, P < 0.05) and OS local recurrence (OR 3.02, 95% CI 1.84–4.94, P < 0.05). In addition, the expressions of CD133 predict metastasis (OR 7.64, 95% CI 4.93–11.85, P < 0.05). Moreover, this study indicated that CD133 expression was correlated to lower 5-year overall survival in OS with the pooled OR of 5.85 (95% CI 3.30–10.37, P < 0.05). Our reported shown that positive expression of CD133 is significantly correlated with ennecking stage, local recurrence, metastasis and low 5-year overall survival rate of OS patients.

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Cluster of differentiation 133




China National Knowledge Internet database


Chinese Biological Medical Database


Newcastle–Ottawa Quality Assessment Scale


Odds ratio

95% CI:

95% confidence interval


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This work was supported by the Mittal Innovation Project of Central South University (Grant No. GCX20190879Y), the Fundamental Research Funds for the Central Universities of Central South University (Grant No. 2018zzts930), the Central South University Sports Medicine Scholarship, the National College Students’ Innovation and Entrepreneurship Training Program (Grant No. 201710422116).

Author information

NX, JZ, WW: Data curation. NX, YK, JZ: Formal analysis. NX, JZ: Funding acquisition. NX, JZ, WW: Investigation. NX, JZ, YK, WW: Methodology. JZ, YK, WW: Writing—original draft. JZ, WW: Writing—review & editing.

Correspondence to Yijun Kang or Wanchun Wang or Jian Zhou.

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Xu, N., Kang, Y., Wang, W. et al. The prognostic role of CD133 expression in patients with osteosarcoma. Clin Exp Med (2020).

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  • CD133
  • Bone tumor
  • Osteosarcoma
  • Clinicopathological features
  • Prognosis
  • Meta-analysis