Clinical and Experimental Medicine

, Volume 18, Issue 4, pp 505–512 | Cite as

Impact of serum soluble programed death ligand 1 on end of treatment metabolic response of diffuse large B cell lymphoma patients

  • Amro Mohamed Sedky El-GhammazEmail author
  • Hoda Ahmed Gadallah
  • Gihan Kamal
  • Mohammed Magdy Maher
  • Mohamad Ayed Mohamad
Original Article


Programmed death ligand-1 (PD-L1) plays an important role in the immune evasion of cancer cells and, in turn, can influence the outcome of many malignancies. The serum soluble PD-L1 (sPD-L1) levels were measured in diffuse large B cell lymphoma (DLBCL) patients at diagnosis and at end of treatment. Their impact on end of treatment metabolic response was analyzed. Serum sPD-L1 level was significantly elevated in DLBCL patients at diagnosis than in controls (P < 0.001). Also, serum sPD-L1 level at diagnosis was significantly higher than that at end of treatment (P < 0.001). Patients who achieved partial response (PR) had significantly higher serum sPD-L1 level at end of treatment than controls (P < 0.001). In contrast, all patients especially those who achieved complete response (CR) had insignificantly different serum sPD-L1 level at end of treatment than controls (P = 0.354 and P = 0.090, respectively). There was a significant difference between serum sPD-L1 level at diagnosis and that at end of treatment in patients who achieved PR and CR (P = 0.023 and P < 0.001, respectively). On univariate analysis, presence of comorbidities, Ann Arbor stage IV, high serum sPD-L1 level at diagnosis and high serum sPD-L1 level at end of treatment were significantly associated with achievement of PR (P = 0.018 and P = 0.043, P = 0.045 and P < 0.001, respectively). On multivariate analysis, serum sPD-L1 levels at diagnosis and at end of treatment were still influencing metabolic response significantly (P = 0.014 and P = 0.007, respectively). Serum sPD-L1 is a predictor for metabolic response to immunochemotherapy in DLBCL patients.


Diffuse large B cell lymphoma Serum soluble programed death ligand 1 End of treatment response Positron emission tomography-computed tomography 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the ethical committee of Faculty of Medicine, Ain Shams University, and with the 1964 Helsinki Declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

10238_2018_506_MOESM1_ESM.pdf (92 kb)
Supplementary material 1 (PDF 92 kb)


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Clinical Hematology and Bone Marrow Transplantation Unit, Internal Medicine Department, Faculty of MedicineAin Shams UniversityCairoEgypt
  2. 2.Hematology and Oncology DepartmentInternational Medical CenterCairoEgypt
  3. 3.Clinical Pathology Department, Faculty of MedicineMansoura UniversityMansouraEgypt

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