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Effects of red blood cell aggregation on the blood flow in a symmetrical stenosed microvessel

  • L. L. XiaoEmail author
  • C. S. Lin
  • S. Chen
  • Y. Liu
  • B. M. Fu
  • W. W. Yan
Original Paper

Abstract

In order to figure out whether red blood cell (RBC) aggregation is beneficial or deleterious for the blood flow through a stenosis, fluid mechanics of a microvascular stenosis was examined through simulating the dynamics of deformable red blood cells suspended in plasma using dissipative particle dynamics. The spatial variation in time-averaged cell-free layer (CFL) thickness and velocity profiles indicated that the blood flow exhibits asymmetry along the flow direction. The RBC accumulation occurs upstream the stenosis, leading to a thinner CFL and reduced flow velocity. Therefore, the emergence of stenosis produces an increased blood flow resistance. In addition, an enhanced Fahraeus–Lindqvist effect was observed in the presence of the stenosis. Finally, the effect of RBC aggregation combined with decreased stenosis on the blood flow was investigated. The findings showed that when the RBC clusters pass through the stenosis with a throat comparable to the RBC core in diameter, the blood flow resistance decreases with increasing intercellular interaction strength. But if the RBC core is larger and even several times than the throat, the blood flow resistance increases largely under strong RBC aggregation, which may contribute to the mechanism of the microthrombus formation.

Keywords

Stenosed microvessel Dissipative particle dynamics RBC core CFL RBC aggregation 

Notes

Acknowledgements

This work is supported by the National Natural Science Foundation of China (Grant No. 11872283), the National Natural Science Foundation of China (Grant No. 11872062), Shanghai Science and Technology Talent Program (19YF1417400) and the Starting Research Fund from Shanghai University of Engineering Science (E3-0501-18-01024). The grants are gratefully acknowledged.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Mechanical and Automotive EngineeringShanghai University of Engineering ScienceShanghaiChina
  2. 2.School of Aerospace Engineering and Applied MechanicsTongji UniversityShanghaiChina
  3. 3.Department of Mechanical EngineeringThe Hong Kong Polytechnic UniversityHong KongChina
  4. 4.Department of Biomedical EngineeringThe City College of the City University of New YorkNew YorkUSA
  5. 5.College of Metrology and Measurement EngineeringChina Jiliang UniversityHangzhouChina

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