Model of dissolution in the framework of tissue engineering and drug delivery
Dissolution phenomena are ubiquitously present in biomaterials in many different fields. Despite the advantages of simulation-based design of biomaterials in medical applications, additional efforts are needed to derive reliable models which describe the process of dissolution. A phenomenologically based model, available for simulation of dissolution in biomaterials, is introduced in this paper. The model turns into a set of reaction–diffusion equations implemented in a finite element numerical framework. First, a parametric analysis is conducted in order to explore the role of model parameters on the overall dissolution process. Then, the model is calibrated and validated versus a straightforward but rigorous experimental setup. Results show that the mathematical model macroscopically reproduces the main physicochemical phenomena that take place in the tests, corroborating its usefulness for design of biomaterials in the tissue engineering and drug delivery research areas.
KeywordsDissolution Reaction–diffusion equations Computational simulation Tissue engineering Drug delivery
This work was supported by the Ministry of Economy and Competitiveness of the State General Administration of Spain under the Grant MAT2015-71284-P. The authors would like to thank technician M. Sánchez for assistance in the manufacture and dissolution of the green pellets.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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