Abstract
An 81-year-old man who had previously shown high levels of alkaline phosphatase (ALP), γ-glutamyltransferase (GTP), and total bilirubin presented with acute liver damage. He was positive for serum anti-gp210 and anti-p62 antibodies, but negative for serum antimitochondrial antibody. A liver biopsy revealed massive interstitial fibrosis and pseudolobulus, which were compatible with a diagnosis of primary biliary cirrhosis (PBC) at Scheuer's stage 4. He was given ursodeoxycolic acid at 600 mg/day. However, his condition deteriorated, and he eventually died of hepatic insufficiency in a state of malnutrition. We hypothesize that the presence of anti-gp210 and anti-p62 complex protein antibodies, rather than that of antimitochondrial antibodies, was correlated with the progression of PBC in this particular case.
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Received: December 18, 2000 / Accepted: December 26, 2001
Acknowledgments We thank Dr. Eng M. Tan of the W.M. Keck Foundation, Scripps Research Institute, LaJolla, California, USA, for the determination of antilamina-associated polypeptide (LAP)-2 antibodies in the SS patient included as a control in this study. We also thank Dr. P.A. Berg of Tubingen University for the determination of anti-M4 and anti-M8 antibodies.
Correspondence to: K. Miyachi
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Miyachi, K., Horigome, T., Matsuoka, Y. et al. A male patient who developed late-onset primary biliary cirrhosis presenting with antinuclear envelope antibodies. Mod Rheumatol 12, 0246–0249 (2002). https://doi.org/10.1007/s101650200043
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DOI: https://doi.org/10.1007/s101650200043