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Sleep debt and prevalence of proteinuria in subjects with short sleep duration on weekdays: a cross-sectional study

  • Katsunori Aoki
  • Ryohei YamamotoEmail author
  • Maki Shinzawa
  • Yoshiki Kimura
  • Hiroyoshi Adachi
  • Yoshiyuki Fujii
  • Ryohei Tomi
  • Kaori Nakanishi
  • Manabu Taneike
  • Makoto Nishida
  • Takashi Kudo
  • Keiko Yamauchi-Takihara
  • Yoshitaka Isaka
  • Toshiki Moriyama
Original article
  • 40 Downloads

Abstract

Study objective

Short sleep duration is a risk factor of chronic kidney disease, along with cardiovascular diseases and all-cause mortality. Several studies reported that many people sleep longer on weekends than on weekdays, suggesting that they should be compensated for their sleep debt on weekdays on the weekends. Few studies have reported the clinical impact of sleep debt on the kidney.

Methods

This cross-sectional study included 5799 employees of Osaka University who visited its Health Care Center for their annual health examinations and answered ≤ 6 h of sleep duration on weekdays. The independent variable was the sleep debt index defined as a gap in self-reported sleep duration (≤ 5, 5–6, 6–7, 7–8, 8–9, and ≥ 9 h) between weekdays and weekends, which was categorized into ≤ 0, + 1, + 2, + 3 and ≥+4. An association between the sleep debt index and a prevalence of proteinuria defined as dipstick proteinuria of ≥ 1 + was assessed using logistic regression models adjusting for clinically relevant factors.

Results

More than four-fifths of the subjects had a positive sleep debt index (≤ 0, + 1, + 2, + 3, and ≥+4 recorded for 19%, 36%, 28%, 11%, and 6%, respectively). The multivariable-adjusted logistic regression models showed the sleep debt index ≥ 3 + was significantly associated with the prevalence of proteinuria (sleep debt index ≤ 0, adjusted odds ratio 1.13 [0.77, 1.65]; + 1, 1.00 [reference]; + 2, 1.29 [0.93, 1.79]; + 3, 1.54 [1.02, 2.33]; ≥ + 4, 1.87 [1.15, 3.05]).

Conclusions

Sleep debt was associated with the prevalence of proteinuria in a dose-dependent manner.

Keywords

Sleep deprivation Sleep debt Sleep duration Proteinuria Health checkup 

Notes

Acknowledgements

We thank all the staff members of Health and Counseling Center, Osaka University for their contributions to the database of the present cohort.

Compliance with ethical standards

Conflict of interest

All the authors have declared no competing interest.

Ethical approval

The study protocol was approved by the ethics committees of Osaka University Health and Counseling Center (No. 2016-1) and Osaka University Hospital (No. 17009-2).

Informed consent

Informed consent was not obtained from participants, according to Japanese Ethical Guidelines for Medical and Health Research Involving Human Subjects.

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Copyright information

© Japanese Society of Nephrology 2019

Authors and Affiliations

  • Katsunori Aoki
    • 1
  • Ryohei Yamamoto
    • 1
    • 2
    Email author
  • Maki Shinzawa
    • 1
  • Yoshiki Kimura
    • 1
  • Hiroyoshi Adachi
    • 2
  • Yoshiyuki Fujii
    • 1
  • Ryohei Tomi
    • 1
  • Kaori Nakanishi
    • 2
  • Manabu Taneike
    • 2
  • Makoto Nishida
    • 2
  • Takashi Kudo
    • 2
  • Keiko Yamauchi-Takihara
    • 2
  • Yoshitaka Isaka
    • 1
  • Toshiki Moriyama
    • 1
    • 2
  1. 1.Department of NephrologyOsaka University Graduate School of MedicineSuitaJapan
  2. 2.Health Care Division, Health and Counseling CenterOsaka UniversityToyonakaJapan

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