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Low birth weight is associated with decline in renal function in Japanese male and female adolescents

  • Ayano Murai-Takeda
  • Takeshi KandaEmail author
  • Tatsuhiko Azegami
  • Hiroshi Hirose
  • Mikako Inokuchi
  • Hirobumi Tokuyama
  • Shu Wakino
  • Mitsuaki Tokumura
  • Hiroshi Kawabe
  • Masaaki Mori
  • Hiroshi Itoh
Original article
  • 36 Downloads

Abstract

Background

Low birth weight (LBW) is a risk factor for chronic kidney disease (CKD) in later life and is becoming increasingly common in developed countries, including Japan. Furthermore, a serial decrease in birth weight has been associated with an increasing prevalence of CKD stage 2 in male Japanese adolescents. Sex-specific differences affect CKD susceptibility, and the association between birth weight and CKD in women, has not been elucidated. In this study, we investigated the sex-specific effect of LBW on renal function.

Methods

Annual cross-sectional data of 2417 Japanese adolescents (males 1736; females 681), aged 15–16 years, were evaluated over 8 years (2007–2014).

Results

Over the study period, mean birth weights decreased significantly in males (p < 0.01) and females (p < 0.05). Furthermore, both sexes showed significant decrease in estimated glomerular filtration rates corresponding to the birth weight reduction. The prevalence of CKD stage 2 also increased in males (from 26.0 to 32.4%, p < 0.01) and females (from 6.3 to 18.5%, p < 0.05). The incidence of CKD stage 2 was significantly related to history of LBW (males: odds ratio 1.73; 95% confidence interval 1.06–2.80; p < 0.05; females: odds ratio 3.29; 95% confidence interval 1.25–8.02; p < 0.05).

Conclusions

Our data revealed that renal function and birth weight have decreased over time, in healthy Japanese adolescents. In view of the recent declining trend demonstrated by birth weight in Japan, we speculate that the prevalence of CKD might increase in the future.

Keywords

Low birth weight Sex differences eGFR 

Notes

Funding

This work was supported by the Daiwa Securities Health Foundation.

Compliance with ethical standards

Conflicts of interest

The authors have declared that no conflict of interest exists.

Ethical approval

The study protocol was approved by the review committee of Keio University (approval number 18-001) and was conducted in accordance with the Declaration of Helsinki.

Informed consent

General informed consent was obtained according to the local ethical committee guidelines.

References

  1. 1.
    Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major non-communicable diseases. Kidney Int. 2011;80(12):1258–70.  https://doi.org/10.1038/ki.2011.368.CrossRefGoogle Scholar
  2. 2.
    Nagata M, Ninomiya T, Doi Y, Yonemoto K, Kubo M, Hata J, et al. Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study. Nephrol Dial Transpl. 2010;25(8):2557–644.  https://doi.org/10.1093/ndt/gfq062.CrossRefGoogle Scholar
  3. 3.
    Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298(17):2038–47.  https://doi.org/10.1001/jama.298.17.2038.CrossRefGoogle Scholar
  4. 4.
    Luyckx VA, Brenner BM. Birth weight, malnutrition and kidney-associated outcomes—a global concern. Nat Rev Nephrol. 2015;11(3):135–49.  https://doi.org/10.1038/nrneph.2014.251.CrossRefGoogle Scholar
  5. 5.
    Hughson M, Farris AB 3rd, Douglas-Denton R, Hoy WE, Bertram JF. Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int. 2003;63(6):2113–222.  https://doi.org/10.1046/j.1523-1755.2003.00018.x.CrossRefGoogle Scholar
  6. 6.
    Manalich R, Reyes L, Herrera M, Melendi C, Fundora I. Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int. 2000;58(2):770–3.  https://doi.org/10.1046/j.1523-1755.2000.00225.x.CrossRefGoogle Scholar
  7. 7.
    Brenner BM, Lawler EV, Mackenzie HS. The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int. 1996;49(6):1774–7.  https://doi.org/10.1038/ki.1996.265.CrossRefGoogle Scholar
  8. 8.
    Schreuder MF, Nyengaard JR, Fodor M, van Wijk A, de Delemarre-van Waal HA. Glomerular number and function are influenced by spontaneous and induced low birth weight in rats. J Am Soc Nephrol. 2005;16(10):2913–9.  https://doi.org/10.1681/asn.2004100875.CrossRefGoogle Scholar
  9. 9.
    Whincup PH, Kaye SJ, Owen CG, Huxley R, Cook DG, Anazawa S, et al. Birth weight and risk of type 2 diabetes: a systematic review. JAMA. 2008;300(24):2886–977.  https://doi.org/10.1001/jama.2008.886.CrossRefGoogle Scholar
  10. 10.
    White SL, Perkovic V, Cass A, Chang CL, Poulter NR, Spector T, et al. Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies. Am J Kidney Dis. 2009;54(2):248–61.  https://doi.org/10.1053/j.ajkd.2008.12.042.CrossRefGoogle Scholar
  11. 11.
    Huxley R, Neil A, Collins R. Unravelling the fetal origins hypothesis: is there really an inverse association between birthweight and subsequent blood pressure? Lancet. 2002;360(9334):659–65.  https://doi.org/10.1016/s0140-6736(02)09834-3.CrossRefGoogle Scholar
  12. 12.
    Organization for Economic Coperation and Development. 2019. OECD Family Database [database on the Internet]. https://www.oecd.org/els/family/CO_1_3_Low_birth_weight.pdf. Accessed 1 Feb 2019
  13. 13.
    Oken E. Secular trends in birthweight. Nestle Nutr Inst Workshop Ser. 2013;71:103–14.  https://doi.org/10.1159/000342576.CrossRefGoogle Scholar
  14. 14.
    Gluckman PD, Seng CY, Fukuoka H, Beedle AS, Hanson MA. Low birthweight and subsequent obesity in Japan. Lancet. 2007;369(9567):1081–2.  https://doi.org/10.1016/s0140-6736(07)60524-8.CrossRefGoogle Scholar
  15. 15.
    Takemoto Y, Ota E, Yoneoka D, Mori R, Takeda S. Japanese secular trends in birthweight and the prevalence of low birthweight infants during the last three decades: a population-based study. Sci Rep. 2016;6:31396.  https://doi.org/10.1038/srep31396.CrossRefGoogle Scholar
  16. 16.
    Kanda T, Takeda A, Hirose H, Abe T, Urai H, Inokuchi M, et al. Temporal trends in renal function and birthweight in Japanese adolescent males (1998–2015). Nephrol Dial Transpl. 2018;33(2):304–10.  https://doi.org/10.1093/ndt/gfw428.CrossRefGoogle Scholar
  17. 17.
    Iseki K. Gender differences in chronic kidney disease. Kidney Int. 2008;74(4):415–7.  https://doi.org/10.1038/ki.2008.261.CrossRefGoogle Scholar
  18. 18.
    Carrero JJ. Gender differences in chronic kidney disease: underpinnings and therapeutic implications. Kidney Blood Press Res. 2010;33(5):383–92.  https://doi.org/10.1159/000320389.CrossRefGoogle Scholar
  19. 19.
    Neugarten J, Acharya A, Silbiger SR. Effect of gender on the progression of non-diabetic renal disease a meta-analysis. J Am Soc Nephrol. 2000;11(2):319–29Google Scholar
  20. 20.
    Eriksson JG, Salonen MK, Kajantie E, Osmond C. Prenatal growth and CKD in older adults: longitudinal findings from the Helsinki birth cohort study, 1924–1944. Am J Kidney Dis. 2018;71(1):20–6.  https://doi.org/10.1053/j.ajkd.2017.06.030.CrossRefGoogle Scholar
  21. 21.
    Li S, Chen SC, Shlipak M, Bakris G, McCullough PA, Sowers J, et al. Low birth weight is associated with chronic kidney disease only in men. Kidney Int. 2008;73(5):637–42.  https://doi.org/10.1038/sj.ki.5002747.CrossRefGoogle Scholar
  22. 22.
    Lackland DT, Bendall HE, Osmond C, Egan BM, Barker DJ. Low birth weights contribute to the high rates of early-onset chronic renal failure in the southeastern United States. Arch Intern Med. 2000;160(10):1472–6.  https://doi.org/10.1001/archinte.160.10.1472.CrossRefGoogle Scholar
  23. 23.
    Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, et al. The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2014). Hypertens Res. 2014;37(4):253–390.  https://doi.org/10.1038/hr.2014.20.CrossRefGoogle Scholar
  24. 24.
    Uemura O, Nagai T, Ishikura K, Ito S, Hataya H, Gotoh Y, et al. Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease. Clin Exp Nephrol. 2014;18(4):626–33.  https://doi.org/10.1007/s10157-013-0856-y.CrossRefGoogle Scholar
  25. 25.
    Levey AS, Coresh J, Bolton K, Culleton B, Harvey KS, Ikizler TA, Johnson CA, Kausz A, Kimmel PL, Kusek J, Levin A. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2 Suppl 1):S1–266.  https://doi.org/10.1053/ajkd.2002.30943.Google Scholar
  26. 26.
    Asamoah-Odei E, Garcia Calleja JM, Boerma JT. HIV prevalence and trends in sub-Saharan Africa: no decline and large subregional differences. Lancet. 2004;364(9428):35–40.  https://doi.org/10.1016/s0140-6736(04)16587-2.CrossRefGoogle Scholar
  27. 27.
    Inokuchi M, Hasegawa T, Anzo M, Matsuo N. Standardized centile curves of body mass index for Japanese children and adolescents based on the 1978–1981 National Survey Data. Ann Hum Biol. 2006;33(4):444–53.  https://doi.org/10.1080/03014460600802353.CrossRefGoogle Scholar
  28. 28.
    Abitbol CL, Moxey-Mims M. Chronic kidney disease: low birth weight and the global burden of kidney disease. Nat Rev Nephrol. 2016.  https://doi.org/10.1038/nrneph.2016.19.Google Scholar
  29. 29.
    Ministry of Health, Labour and Welfare. 2019. Vital statistics in Japan [database on the Internet]. https://www.mhlw.go.jp/english/database/db-hw/vs01.html. Accessed 1 Mar 2019
  30. 30.
    Tsukamoto H, Fukuoka H, Koyasu M, Nagai Y, Takimoto H. Risk factors for small for gestational age. Pediatr Int. 2007;49(6):985–90.  https://doi.org/10.1111/j.1442-200X.2007.02494.x.CrossRefGoogle Scholar
  31. 31.
    Xu R, Zhang L-X, Zhang P-H, Wang F, Zuo L, Wang H-Y. Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients. BMC Nephrol. 2010;11(1):20.  https://doi.org/10.1186/1471-2369-11-20.CrossRefGoogle Scholar
  32. 32.
    Uemura O, Nagai T, Ishikura K, Ito S, Hataya H, Gotoh Y, et al. Reference glomerular filtration rate levels in Japanese children: using the creatinine and cystatin C based estimated glomerular filtration rate. Clin Exp Nephrol. 2015;19(4):683–7.  https://doi.org/10.1007/s10157-014-1042-6.CrossRefGoogle Scholar
  33. 33.
    Blush J, Lei J, Ju W, Silbiger S, Pullman J, Neugarten J. Estradiol reverses renal injury in Alb/TGF-beta1 transgenic mice. Kidney Int. 2004;66(6):2148–54.  https://doi.org/10.1111/j.1523-1755.2004.66005.x.CrossRefGoogle Scholar
  34. 34.
    Negulescu O, Bognar I, Lei J, Devarajan P, Silbiger S, Neugarten J. Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanism. Kidney Int. 2002;62(6):1989–98.  https://doi.org/10.1046/j.1523-1755.2002.00679.x.CrossRefGoogle Scholar
  35. 35.
    Kattah AG, Smith CY, Gazzuola Rocca L, Grossardt BR, Garovic VD, Rocca WA. CKD in patients with bilateral oophorectomy. Clin J Am Soc Nephrol. 2018;13(11):1649–58.  https://doi.org/10.2215/CJN.03990318.CrossRefGoogle Scholar
  36. 36.
    Silbiger S, Neugarten J. Gender and human chronic renal disease. Gend Med. 2008;5(Suppl A):S3–S10.  https://doi.org/10.1016/j.genm.2008.03.002.CrossRefGoogle Scholar
  37. 37.
    Hoy WE, Rees M, Kile E, Mathews JD, McCredie DA, Pugsley DJ, et al. Low birthweight and renal disease in Australian aborigines. Lancet. 1998;352(9143):1826–7.  https://doi.org/10.1016/s0140-6736(05)79888-3.CrossRefGoogle Scholar
  38. 38.
    Nagai M, Ohkubo T, Murakami Y, Takashima N, Kadota A, Miyagawa N, et al. Secular trends of the impact of overweight and obesity on hypertension in Japan, 1980–2010. Hypertens Res. 2015;38(11):790.  https://doi.org/10.1038/hr.2015.81.CrossRefGoogle Scholar
  39. 39.
    Lawlor DA, Owen CG, Davies AA, Whincup PH, Ebrahim S, Cook DG, et al. Sex differences in the association between birth weight and total cholesterol. A meta-analysis. Ann Epidemiol. 2006;16(1):19–25.  https://doi.org/10.1016/j.annepidem.2005.04.006.CrossRefGoogle Scholar
  40. 40.
    Franco MC, Christofalo DM, Sawaya AL, Ajzen SA, Sesso R. Effects of low birth weight in 8- to 13-year-old children: implications in endothelial function and uric acid levels. Hypertension. 2006;48(1):45–50.  https://doi.org/10.1161/01.HYP.0000223446.49596.3a.CrossRefGoogle Scholar
  41. 41.
    Feig DI, Nakagawa T, Karumanchi SA, Oliver WJ, Kang DH, Finch J, et al. Hypothesis: uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int. 2004;66(1):281–7.  https://doi.org/10.1111/j.1523-1755.2004.00729.x.CrossRefGoogle Scholar

Copyright information

© Japanese Society of Nephrology 2019

Authors and Affiliations

  • Ayano Murai-Takeda
    • 1
  • Takeshi Kanda
    • 2
    Email author
  • Tatsuhiko Azegami
    • 1
  • Hiroshi Hirose
    • 1
  • Mikako Inokuchi
    • 1
  • Hirobumi Tokuyama
    • 2
  • Shu Wakino
    • 2
  • Mitsuaki Tokumura
    • 1
  • Hiroshi Kawabe
    • 1
  • Masaaki Mori
    • 1
  • Hiroshi Itoh
    • 2
  1. 1.Health CenterKeio UniversityYokohamaJapan
  2. 2.Department of Internal Medicine, School of MedicineKeio UniversityTokyoJapan

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