Clinical and Experimental Nephrology

, Volume 23, Issue 10, pp 1250–1256 | Cite as

The association between cardiac valvular calcification and fetuin-A levels in kidney transplant recipients

  • Nizameddin KocaEmail author
  • Alparslan Ersoy
  • Barış Şensoy
  • Emine Kırhan
  • Sümeyye Güllülü
  • Canan Ersoy
  • Melahat Dirican
  • Emre Sarandöl
Original article



Low fetuin-A levels in hemodialysis patients can be associated with development of vascular and valvular calcifications. The mechanisms underlying vascular and valvular calcifications are multifactorial. There are a few studies showing the relationship between low fetuin-A levels and valvular calcification after kidney transplantation. We aimed to evaluate the association between serum fetuin-A levels and valvular calcification in kidney transplant recipients.


The cardiac valvular calcification was assessed by echocardiography in 56 recipients. Patients were divided into two groups as those with (n = 11) and without (n = 45) aortic and/or mitral valve calcification. The extent of valvular calcification was visually assessed according to the standard visual score method: moderately (multiple larger spots) and heavily calcified (extensive thickening and calcification) of all cusps. Serum fetuin-A levels were measured.


The demographic features of both groups were comparable. There was no significant difference between regular physical exercise (63.6% vs. 55.6%), obesity (18.2% vs. 17.8%), abdominal obesity (54.5% vs. 46.7%), smoking (0% vs. 13.3%), hypertension (63.6% vs. 68.9%), left ventricular hypertrophy (45.5% vs. 33.3%) and diabetes mellitus (9.1% vs. 20%) ratios in groups with or without valvular calcification, respectively (p > 0.05). Fetuin-A levels of both groups did not differ. Fetuin-A levels positively correlated with serum creatinine (r 0.326, p = 0.014), and negatively correlated with estimated glomerular filtration rate (r − 0.297, p = 0.026).


We could not find a relationship between serum fetuin-A levels and valvular calcification in kidney recipients. In this population, further studies are needed to assess the role of serum fetuin-A in valvular calcification.


Kidney transplantation Valvular calcification Fetuin A 


Compliance with ethical standards

Conflict of interest

There is no conflict of interest.

Ethical approval

Ethical approval for human and animal rights (with IRB Approval number: 2009-11/77) was obtained.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Japanese Society of Nephrology 2019

Authors and Affiliations

  1. 1.Department of Internal Medicine, University of Health SciencesBursa Yuksek Ihtisas Training and Research HospitalBursaTurkey
  2. 2.Department of Nephrology and TransplantationUludag UniversityBursaTurkey
  3. 3.Department of Cardiology, University of Health SciencesBursa Yuksek Ihtisas Training and Research HospitalBursaTurkey
  4. 4.Department of BiochemistryTavsanli State HospitalKutahyaTurkey
  5. 5.Department of CardiologyUludag UniversityBursaTurkey
  6. 6.Department of Endocrinology and MetabolismUludag UniversityBursaTurkey
  7. 7.Department of BiochemistryUludag UniversityBursaTurkey

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