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The clinical characteristics of Chinese patients with unilateral renal agenesis

  • Qian Xu
  • Hangdi Wu
  • Lihan Zhou
  • Jingyuan Xie
  • Wen Zhang
  • Haijin Yu
  • Weiming Wang
  • Ying Qian
  • Qianying Zhang
  • Panpan Qiao
  • Yonghua Tang
  • Xiaonong Chen
  • Zhaohui WangEmail author
  • Nan Chen
Original article
  • 9 Downloads

Abstract

Background

We aimed to investigate the clinical characteristics of Chinese patients with unilateral renal agenesis.

Methods

We enrolled patients with unilateral renal agenesis diagnosed radiologically at the Department of Nephrology from January 2008 to January 2016. Patients with a solitary kidney due to nephrectomy or renal atrophy due to secondary factors were excluded. Clinical data were recorded and analyzed.

Results

In this study, 118 Chinese patients with unilateral renal agenesis were recruited, and the gender ratio (male/female) was 1.11:1. A total of 14 (11.9%) patients had additional abnormalities, 15 (12.7%) had a family history, and 30 (25.4%) presented with renal insufficiency. Kidney length, serum creatinine level and estimated glomerular filtration rate were significantly different between patients with and without family history (P < 0.05, respectively). Gender showed a significant difference between patients with and without other abnormalities. Kidney length and the incidence of proteinuria, hematuria, hypertension, and hyperuricemia were significantly different between patients with and without renal insufficiency. Logistic regression analysis revealed that family history was associated with severe renal failure (OR = 7.11, 95% CI 1.52–33.25).

Conclusion

Renal insufficiency is common in patients with unilateral renal agenesis. Patients with renal insufficiency have shorter kidney lengths and a higher incidence of proteinuria, hypertension, hematuria, and hyperuricemia. Family history is considered a risk factor for severe renal failure.

Keywords

Unilateral renal agenesis Clinical characteristics Renal insufficiency Chinese population 

Notes

Acknowledgements

We are grateful to our patients and their families for participating in this study. This work is the result of a collaborative effort of the Nephrology and Radiology Department of Ruijin Hospital, Shanghai Jiao Tong University, China.

Author contributions

Conceived and designed the experiments: ZW, JX, NC. Performed the experiments: QX, HW, LZ, WZ, HY, WW, YQ, QZ, PQ. Analyzed the data: QX, HW. Contributed reagents/materials/analysis tools: YT, XC. Wrote the paper: QX, HW, LZ.

Funding

This study was supported by the National Basic Research Program of China 973 Program (No. 2012CB517604) and National Natural Science Foundation of China (Nos. 81170634, 81570598, 81370015).

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Copyright information

© Japanese Society of Nephrology 2019

Authors and Affiliations

  • Qian Xu
    • 1
  • Hangdi Wu
    • 1
  • Lihan Zhou
    • 1
  • Jingyuan Xie
    • 1
  • Wen Zhang
    • 1
  • Haijin Yu
    • 1
  • Weiming Wang
    • 1
  • Ying Qian
    • 1
  • Qianying Zhang
    • 1
  • Panpan Qiao
    • 1
  • Yonghua Tang
    • 2
  • Xiaonong Chen
    • 1
  • Zhaohui Wang
    • 1
    Email author
  • Nan Chen
    • 1
  1. 1.Nephrology Department, Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.Radiology Department, Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

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