Clinical and Experimental Nephrology

, Volume 23, Issue 5, pp 606–612 | Cite as

Evaluation of the safety, effectiveness, and health-related QOL impact of early rehabilitation in patients with nephrotic syndrome

  • Kohji IwaiEmail author
  • Yasuhiko Hatanaka
  • Tamiro kawaguchi
  • Shin-ichi Araki
Original article



The aim of this study was to evaluate the safety, effectiveness, and health-related QOL impact of early rehabilitation in patients with nephrotic syndrome.


Subjects consisted of 23 patients with nephrotic syndrome who had previously received steroid treatment. Patients worked performed quadriceps resistance training and aerobic training 5 days per week for 5 weeks. Urinary protein, albumin (Alb), creatinine (Cre), and blood urea nitrogen (BUN) were monitored once every week over a 5-week period based on medical records. The 36-item short form health survey (SF-36) score was used to evaluate health-related QOL.


There was no significant difference in quadriceps force and no significant effect of age as shown by ANCOVA. Anaerobic threshold (AT) and peak oxygen consumption (peak VO2) both increased significantly. AT was affected by the degree of change in body weight according to ANCOVA. Cre and BUN were not significantly altered. Urinary protein showed a significant decrease and Alb was significantly increased. Only physical function (PF) in the SF-36 showed a significant improvement following the intervention.


Our data indicate that early rehabilitation involving quadriceps resistance training and aerobic training for nephrotic syndrome is safe and effective.


Nephrotic syndrome Rehabilitation Aerobic training Quadriceps resistance training 



The authors acknowledge Professor Toru Yamakado in Suzuka University of Medical Science and thank the people who participated in the study.

Compliance with ethical standards

Conflict of interest

None of the authors have any conflicts of interest to declare in connection with this paper. The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki as reflected in a priori approval by the clinical research ethical committee of Hospital of Shiga University of Medical Science (approval number: 27-187), and informed consent was obtained from all patients enrolled.


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Copyright information

© Japanese Society of Nephrology 2019

Authors and Affiliations

  1. 1.Division of Physical Therapy, Rehabilitation UnitsShiga University of Medical ScienceOtsuJapan
  2. 2.Graduate school of Health ScienceSuzuka University of Medical ScienceSuzukaJapan
  3. 3.Department of rehabilitationShiga University of Medical ScienceOtsuJapan
  4. 4.Department of nephrologyShiga University of Medical ScienceOtsuJapan

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