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Clinical and Experimental Nephrology

, Volume 22, Issue 5, pp 1061–1068 | Cite as

Association between exercise intensity and renal blood flow evaluated using ultrasound echo

  • Shotaro Kawakami
  • Tetsuhiko Yasuno
  • Takuro Matsuda
  • Kanta Fujimi
  • Ai Ito
  • Saki Yoshimura
  • Yoshinari Uehara
  • Hiroaki Tanaka
  • Takao Saito
  • Yasuki HigakiEmail author
Original article

Abstract

Background

High-intensity exercise reduces renal blood flow (RBF) and may transiently exacerbate renal dysfunction. RBF has previously been measured invasively by administration of an indicator material; however, non-invasive measurement is now possible with technological innovations. This study examined variations in RBF at different exercise intensities using ultrasound echo.

Methods

Eight healthy men with normal renal function (eGFRcys 114 ± 19 mL/min/1.73 m2) participated in this study. Using a bicycle ergometer, participants underwent an incremental exercise test using a ramp protocol (20 W/min) until exhaustion in Study 1 and the lactate acid breaking point (LaBP) was calculated. Participants underwent a multi-stage test at exercise intensities of 60, 80, 100, 120, and 140% LaBP in Study 2. RBF was measured by ultrasound echo at rest and 5 min after exercise in Study 1 and at rest and immediately after each exercise in Study 2. To determine the mechanisms behind RBF decline, a catheter was placed into the antecubital vein to study vasoconstriction dynamics.

Results

RBF after maximum exercise decreased by 51% in Study 1. In Study 2, RBF showed no significant decrease until 80% LaBP, and showed a significant decrease (31%) at 100% LaBP compared with at rest (p < 0.01). The sympathetic nervous system may be involved in this reduction in RBF.

Conclusions

RBF showed no significant decrease until 80% LaBP, and decreased with an increase in blood lactate. Reduction in RBF with exercise above the intensity at LaBP was due to decreased cross-sectional area rather than time-averaged flow velocity.

Keywords

Catecholamines Exercise Renal blood flow Ultrasound echo 

Notes

Acknowledgements

The authors thank the volunteers who participated in this study. This work was supported by Fukuoka University Institute for Physical Activity, Fukuoka, Japan.

Compliance with ethical standards

Conflict of interest

The authors have declared that no conflicts of interest exist.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee at which the studies were conducted (Ethics Committee of Fukuoka University Approval No. 15-04-05) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in this study.

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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  • Shotaro Kawakami
    • 1
  • Tetsuhiko Yasuno
    • 2
  • Takuro Matsuda
    • 3
  • Kanta Fujimi
    • 3
  • Ai Ito
    • 4
  • Saki Yoshimura
    • 4
  • Yoshinari Uehara
    • 5
    • 6
  • Hiroaki Tanaka
    • 5
    • 6
  • Takao Saito
    • 2
  • Yasuki Higaki
    • 5
    • 6
    Email author
  1. 1.Department of RehabilitationFukuoka University Chikushi HospitalChikushinoJapan
  2. 2.Division of Nephrology and Rheumatology, Department of Internal MedicineFukuoka University School of MedicineFukuokaJapan
  3. 3.Department of RehabilitationFukuoka University HospitalFukuokaJapan
  4. 4.Graduate School of Sports and Health ScienceFukuoka UniversityFukuokaJapan
  5. 5.Laboratory of Exercise Physiology, Faculty of Health and Sports ScienceFukuoka UniversityFukuokaJapan
  6. 6.The Fukuoka University Institute for Physical ActivityFukuokaJapan

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