Clinical and Experimental Nephrology

, Volume 22, Issue 5, pp 1052–1060 | Cite as

Defective renal autoregulation in the chronic bile duct ligation model of liver failure

  • Tomchika Maoka
  • Tetsuya Kawata
  • Takao Koike
  • Toshio Mochizuki
  • Jurgen Schnermann
  • Seiji HashimotoEmail author
Original article



Cirrhosis of the liver is often associated with an impairment of renal function that is usually not associated with consistent structural abnormalities of the renal parenchyma, but is thought to be the functional consequence of arterial underfilling and reduced arterial blood pressure.


We have used the cirrhosis model of chronic bile duct ligation (BDL) to assess the response of renal blood flow to a change of blood pressure. We have measured renal haemodynamics in BDL rats.


Three weeks after BDL, rats showed elevated levels of total bilirubin, AST, and ALT as well as reduced arterial blood pressure. Creatinine clearance was significantly reduced, and plasma creatinine and urea nitrogen were elevated. Renal blood flow at baseline blood pressure was significantly lower in the BDL group than in the sham group. Clamp-induced reductions of renal perfusion pressure caused significantly greater changes of renal blood flow in BDL than control rats. The autoregulatory index over a comparable blood pressure range averaged 0.28 ± 0.35 in control rats and 1.26 ± 0.6 in BDL rats (p = 0.0004) indicating impairment of renal autoregulation in liver cirrhosis.


Tubuloglomerular feedback (TGF) responses were significantly attenuated in BDL rats, especially in the subnormal flow range. Impairment of renal blood flow autoregulation, to some extent mediated by reduced TGF-mediated vasodilatation, may contribute to the renal vascular constrictor state in liver cirrhosis by preventing the full dilatory response to the blood pressure reduction.


Renal blood flow Autoregulation index Rats Tubuloglomerular feedback 


Compliance with ethical standards

Conflict of interest

The authors have declared that no conflict of interest exists.

Ethical approval

All animal experiments were conducted in accordance with “Hokkaido University Animal Experiment Guidelines”. And all animal experiments were receiving research approval from Hokkaido University animal experiment facility. (2008 − 168).

Informed consent

No relationship. All experiments were done on animals.


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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  1. 1.Department of NephrologyNTT East Japan Sapporo HospitalSapporoJapan
  2. 2.Department of Medicine IIHokkaido University Graduate School of MedicineSapporoJapan
  3. 3.National Institutes of Health, National Institute of Diabetes and Digestive and Kidney DiseasesBethesdaUSA
  4. 4.Department of NephrologyWakayama Medical UniversityWakayamaJapan

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